Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized Kr-83

Joseph S. Six, Theodore Hughes-Riley, David M. L. Lilburn, Alan C. Dorkes, Karl F. Stupic, Dominick E. Shaw, Peter G. Morris, Ian P. Hall, Galina E. Pavlovskaya, Thomas Meersmann*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Hyperpolarized Kr-83 has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the Kr-83 hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched Kr-83, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized Kr-83 MRI after krypton inhalation. Different Kr-83 relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T-1 weighted hyperpolarized Kr-83 MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast. (C) 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Original languageEnglish
Pages (from-to)48-53
Number of pages6
JournalMagnetic Resonance Imaging
Volume32
Issue number1
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Kr-83
  • Krypton-83
  • Kr-83 hyperpolarization
  • Hyperpolarized
  • Noble gas MRI
  • Spin polarization
  • Cryogenic separation
  • Spin-exchange optical pumping
  • Nuclear electric quadrupole moment
  • Quadrupolar relaxation
  • Surface sensitive contrast
  • Pre-clinical MRI
  • Pulmonary MRI
  • Lung surfactant
  • MAGNETIC-RESONANCE
  • HE-3 GAS
  • INITIAL-EXPERIENCE
  • POLARIZED XE-129
  • EMPHYSEMA
  • EXCHANGE
  • KRYPTON
  • LUNGS
  • DIFFUSION
  • PRESSURE

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