Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized Kr-83

Joseph S. Six; Theodore Hughes-Riley; David M. L. Lilburn; Alan C. Dorkes; Karl F. Stupic; Dominick E. Shaw; Peter G. Morris; Ian P. Hall; Galina E. Pavlovskaya; Thomas Meersmann

doi:10.1016/j.mri.2013.08.007

Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized Kr-83

Joseph S. Six, Theodore Hughes-Riley, David M. L. Lilburn, Alan C. Dorkes, Karl F. Stupic, Dominick E. Shaw, Peter G. Morris, Ian P. Hall, Galina E. Pavlovskaya, Thomas Meersmann^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Hyperpolarized Kr-83 has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the Kr-83 hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched Kr-83, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized Kr-83 MRI after krypton inhalation. Different Kr-83 relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T-1 weighted hyperpolarized Kr-83 MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast. (C) 2014 The Authors. Published by Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	48-53
Number of pages	6
Journal	Magnetic Resonance Imaging
Volume	32
Issue number	1
DOIs	https://doi.org/10.1016/j.mri.2013.08.007
Publication status	Published - Jan 2014

Keywords / Materials (for Non-textual outputs)

Kr-83
Krypton-83
Kr-83 hyperpolarization
Hyperpolarized
Noble gas MRI
Spin polarization
Cryogenic separation
Spin-exchange optical pumping
Nuclear electric quadrupole moment
Quadrupolar relaxation
Surface sensitive contrast
Pre-clinical MRI
Pulmonary MRI
Lung surfactant
MAGNETIC-RESONANCE
HE-3 GAS
INITIAL-EXPERIENCE
POLARIZED XE-129
EMPHYSEMA
EXCHANGE
KRYPTON
LUNGS
DIFFUSION
PRESSURE

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10.1016/j.mri.2013.08.007

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@article{24d2a4c80bd94d018eb814c4b38881ad,

title = "Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized Kr-83",

abstract = "Hyperpolarized Kr-83 has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the Kr-83 hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched Kr-83, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized Kr-83 MRI after krypton inhalation. Different Kr-83 relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T-1 weighted hyperpolarized Kr-83 MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast. (C) 2014 The Authors. Published by Elsevier Inc. All rights reserved.",

keywords = "Kr-83, Krypton-83, Kr-83 hyperpolarization, Hyperpolarized, Noble gas MRI, Spin polarization, Cryogenic separation, Spin-exchange optical pumping, Nuclear electric quadrupole moment, Quadrupolar relaxation, Surface sensitive contrast, Pre-clinical MRI, Pulmonary MRI, Lung surfactant, MAGNETIC-RESONANCE, HE-3 GAS, INITIAL-EXPERIENCE, POLARIZED XE-129, EMPHYSEMA, EXCHANGE, KRYPTON, LUNGS, DIFFUSION, PRESSURE",

author = "Six, {Joseph S.} and Theodore Hughes-Riley and Lilburn, {David M. L.} and Dorkes, {Alan C.} and Stupic, {Karl F.} and Shaw, {Dominick E.} and Morris, {Peter G.} and Hall, {Ian P.} and Pavlovskaya, {Galina E.} and Thomas Meersmann",

year = "2014",

month = jan,

doi = "10.1016/j.mri.2013.08.007",

language = "English",

volume = "32",

pages = "48--53",

journal = "Magnetic Resonance Imaging",

issn = "0730-725X",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized Kr-83

AU - Six, Joseph S.

AU - Hughes-Riley, Theodore

AU - Lilburn, David M. L.

AU - Dorkes, Alan C.

AU - Stupic, Karl F.

AU - Shaw, Dominick E.

AU - Morris, Peter G.

AU - Hall, Ian P.

AU - Pavlovskaya, Galina E.

AU - Meersmann, Thomas

PY - 2014/1

Y1 - 2014/1

N2 - Hyperpolarized Kr-83 has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the Kr-83 hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched Kr-83, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized Kr-83 MRI after krypton inhalation. Different Kr-83 relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T-1 weighted hyperpolarized Kr-83 MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast. (C) 2014 The Authors. Published by Elsevier Inc. All rights reserved.

AB - Hyperpolarized Kr-83 has previously been demonstrated to enable MRI contrast that is sensitive to the chemical composition of the surface in a porous model system. Methodological advances have lead to a substantial increase in the Kr-83 hyperpolarization and the resulting signal intensity. Using the improved methodology for spin exchange optical pumping of isotopically enriched Kr-83, internal anatomical details of ex vivo rodent lung were resolved with hyperpolarized Kr-83 MRI after krypton inhalation. Different Kr-83 relaxation times were found between the main bronchi and the parenchymal regions in ex vivo rat lungs. The T-1 weighted hyperpolarized Kr-83 MRI provided a first demonstration of surface quadrupolar relaxation (SQUARE) pulmonary MRI contrast. (C) 2014 The Authors. Published by Elsevier Inc. All rights reserved.

KW - Kr-83

KW - Krypton-83

KW - Kr-83 hyperpolarization

KW - Hyperpolarized

KW - Noble gas MRI

KW - Spin polarization

KW - Cryogenic separation

KW - Spin-exchange optical pumping

KW - Nuclear electric quadrupole moment

KW - Quadrupolar relaxation

KW - Surface sensitive contrast

KW - Pre-clinical MRI

KW - Pulmonary MRI

KW - Lung surfactant

KW - MAGNETIC-RESONANCE

KW - HE-3 GAS

KW - INITIAL-EXPERIENCE

KW - POLARIZED XE-129

KW - EMPHYSEMA

KW - EXCHANGE

KW - KRYPTON

KW - LUNGS

KW - DIFFUSION

KW - PRESSURE

U2 - 10.1016/j.mri.2013.08.007

DO - 10.1016/j.mri.2013.08.007

M3 - Article

SN - 0730-725X

VL - 32

SP - 48

EP - 53

JO - Magnetic Resonance Imaging

JF - Magnetic Resonance Imaging

IS - 1

ER -

Pulmonary MRI contrast using Surface Quadrupolar Relaxation (SQUARE) of hyperpolarized Kr-83

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Keywords / Materials (for Non-textual outputs)

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