Purinergic signalling in the kidney in health and disease

Geoffrey Burnstock; Louise C Evans; Matthew A Bailey

doi:10.1007/s11302-013-9400-5

Purinergic signalling in the kidney in health and disease

Geoffrey Burnstock, Louise C Evans, Matthew A Bailey

Research output: Contribution to journal › Article › peer-review

Abstract

The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly gaining recognition and this is a comprehensive review of early and recent publications in the field. Purinergic signalling involvement is described in several important intrarenal regulatory mechanisms, including tuboglomerular feedback, the autoregulatory response of the glomerular and extraglomerular microcirculation and the control of renin release. Furthermore, purinergic signalling influences water and electrolyte transport in all segments of the renal tubule. Reports about purine- and pyrimidine-mediated actions in diseases of the kidney, including polycystic kidney disease, nephritis, diabetes, hypertension and nephrotoxicant injury are covered and possible purinergic therapeutic strategies discussed.

Original language	English
Journal	Purinergic signalling
DOIs	https://doi.org/10.1007/s11302-013-9400-5
Publication status	Published - 22 Nov 2013

Access to Document

10.1007/s11302-013-9400-5

Cite this

@article{820e4bc967024d4a862df48d8091f8ac,

title = "Purinergic signalling in the kidney in health and disease",

abstract = "The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly gaining recognition and this is a comprehensive review of early and recent publications in the field. Purinergic signalling involvement is described in several important intrarenal regulatory mechanisms, including tuboglomerular feedback, the autoregulatory response of the glomerular and extraglomerular microcirculation and the control of renin release. Furthermore, purinergic signalling influences water and electrolyte transport in all segments of the renal tubule. Reports about purine- and pyrimidine-mediated actions in diseases of the kidney, including polycystic kidney disease, nephritis, diabetes, hypertension and nephrotoxicant injury are covered and possible purinergic therapeutic strategies discussed.",

author = "Geoffrey Burnstock and Evans, {Louise C} and Bailey, {Matthew A}",

year = "2013",

month = nov,

day = "22",

doi = "10.1007/s11302-013-9400-5",

language = "English",

journal = "Purinergic signalling",

issn = "1573-9546",

publisher = "Springer Netherlands",

}

TY - JOUR

T1 - Purinergic signalling in the kidney in health and disease

AU - Burnstock, Geoffrey

AU - Evans, Louise C

AU - Bailey, Matthew A

PY - 2013/11/22

Y1 - 2013/11/22

N2 - The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly gaining recognition and this is a comprehensive review of early and recent publications in the field. Purinergic signalling involvement is described in several important intrarenal regulatory mechanisms, including tuboglomerular feedback, the autoregulatory response of the glomerular and extraglomerular microcirculation and the control of renin release. Furthermore, purinergic signalling influences water and electrolyte transport in all segments of the renal tubule. Reports about purine- and pyrimidine-mediated actions in diseases of the kidney, including polycystic kidney disease, nephritis, diabetes, hypertension and nephrotoxicant injury are covered and possible purinergic therapeutic strategies discussed.

AB - The involvement of purinergic signalling in kidney physiology and pathophysiology is rapidly gaining recognition and this is a comprehensive review of early and recent publications in the field. Purinergic signalling involvement is described in several important intrarenal regulatory mechanisms, including tuboglomerular feedback, the autoregulatory response of the glomerular and extraglomerular microcirculation and the control of renin release. Furthermore, purinergic signalling influences water and electrolyte transport in all segments of the renal tubule. Reports about purine- and pyrimidine-mediated actions in diseases of the kidney, including polycystic kidney disease, nephritis, diabetes, hypertension and nephrotoxicant injury are covered and possible purinergic therapeutic strategies discussed.

U2 - 10.1007/s11302-013-9400-5

DO - 10.1007/s11302-013-9400-5

M3 - Article

C2 - 24265071

JO - Purinergic signalling

JF - Purinergic signalling

SN - 1573-9546

ER -

Purinergic signalling in the kidney in health and disease

Abstract

Access to Document

Fingerprint

Cite this