Pushing the limits of detection of weak binding using fragment based drug discovery: identification of new cyclophilin binders

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• Finished

  Ensemble-based methods for drug design

  Michel, J. (Principal Investigator)

  UK-based charities

  1/10/15 → 30/09/18

  Project: Research

  • Cyclophilin 100%
  • Drug Development 100%
  • Drug Discovery 100%
  • Isoform 75%
  • Protein Family 50%

• Beyond structure: integrated computational and experimental approach to Ensemble-Based Drug Design (EBDD)

  Michel, J. (Principal Investigator)

  EU government bodies

  1/12/13 → 30/11/18

  Project: Research

  • Energy Transfer 100%
  • Binding Site 80%
  • Binding Affinity 64%
  • Small Molecule 50%
  • Binding Protein 40%