Putting pressure on elusive polymorphs and solvates

Iain D. H. Oswald, Isabelle Chataigner, Stephen Elphick, Francesca P. A. Fabbiani, Alistair R. Lennie, Jacques Maddaluno, William G. Marshall, Timothy J. Prior, Colin R. Pulham, Ronald I. Smith

Research output: Contribution to journalArticlepeer-review


The reproducible crystallisation of elusive polymorphs and solvates of molecular compounds at high pressure has been demonstrated through studies on maleic acid, malonamide, and paracetamol. These high-pressure methods can be scaled-up to produce 'bulk' quantities of metastable forms that can be recovered to ambient pressure for subsequent seeding experiments. This has been demonstrated for paracetamol form II and paracetamol monohydrate. The studies also show that the particular solid form can be tuned by both pressure and concentration.

Original languageEnglish
Pages (from-to)359-366
Number of pages8
Issue number2
Publication statusPublished - 2009

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