Putting together and taking apart: assembly and disassembly of the Rad51 nucleoprotein filament in DNA repair and genome stability

Tadas Andriuskevicius; Oleksii Kotenko; Svetlana Makovets

doi:10.15698/cst2018.05.134

Putting together and taking apart: assembly and disassembly of the Rad51 nucleoprotein filament in DNA repair and genome stability

Tadas Andriuskevicius, Oleksii Kotenko, Svetlana Makovets

School of Biological Sciences

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

Homologous recombination is a key mechanism providing both genome stability and genetic diversity in all living organisms. Recombinases play a central role in this pathway: multiple protein subunits of Rad51 or its orthologues bind single-stranded DNA to form a nucleoprotein filament which is essential for initiating recombination events. Multiple factors are involved in the regulation of this step, both positively and negatively. In this review, we discuss Rad51 nucleoprotein assembly and disassembly, how it is regulated and what functional significance it has in genome maintenance.

Original language	English
Pages (from-to)	96 - 112
Number of pages	17
Journal	Cell Stress
DOIs	https://doi.org/10.15698/cst2018.05.134
Publication status	Published - 28 Mar 2018

Keywords / Materials (for Non-textual outputs)

homologous recombination
Rad51 filament
double-stranded DNA break
DNA repair
Rad51 regulation

Access to Document

10.15698/cst2018.05.134Licence: Creative Commons: Attribution (CC-BY)

2018A-Andriuskevicius-Cell-Stress-Advanced-Pub
© 2018 Andriuskevicius et al. This is an open-access article released under the terms of the Creative Commons Attribution (CC BY) license, which allows the unrestricted use, distribution, and reproduction in any medium, provided the original author and source are acknowledged.
Final published version, 1.03 MBLicence: Creative Commons: Attribution (CC-BY)

Proteolysis-dependent regulation of telomerase catalytic subunit
Makovets, S., Buonomo, S. & Granneman, S.
UK-based charities
1/05/17 → 30/04/20
Project: Research

Cite this

@article{2687ffac0aff476998ee924b579f725b,

title = "Putting together and taking apart: assembly and disassembly of the Rad51 nucleoprotein filament in DNA repair and genome stability",

abstract = "Homologous recombination is a key mechanism providing both genome stability and genetic diversity in all living organisms. Recombinases play a central role in this pathway: multiple protein subunits of Rad51 or its orthologues bind single-stranded DNA to form a nucleoprotein filament which is essential for initiating recombination events. Multiple factors are involved in the regulation of this step, both positively and negatively. In this review, we discuss Rad51 nucleoprotein assembly and disassembly, how it is regulated and what functional significance it has in genome maintenance.",

keywords = "homologous recombination, Rad51 filament, double-stranded DNA break, DNA repair, Rad51 regulation",

author = "Tadas Andriuskevicius and Oleksii Kotenko and Svetlana Makovets",

year = "2018",

month = mar,

day = "28",

doi = "10.15698/cst2018.05.134",

language = "English",

pages = "96 -- 112",

journal = "Cell Stress",

issn = "2523-0204",

publisher = "Shared Science Publishers OG",

}

TY - JOUR

T1 - Putting together and taking apart: assembly and disassembly of the Rad51 nucleoprotein filament in DNA repair and genome stability

AU - Andriuskevicius, Tadas

AU - Kotenko, Oleksii

AU - Makovets, Svetlana

PY - 2018/3/28

Y1 - 2018/3/28

N2 - Homologous recombination is a key mechanism providing both genome stability and genetic diversity in all living organisms. Recombinases play a central role in this pathway: multiple protein subunits of Rad51 or its orthologues bind single-stranded DNA to form a nucleoprotein filament which is essential for initiating recombination events. Multiple factors are involved in the regulation of this step, both positively and negatively. In this review, we discuss Rad51 nucleoprotein assembly and disassembly, how it is regulated and what functional significance it has in genome maintenance.

AB - Homologous recombination is a key mechanism providing both genome stability and genetic diversity in all living organisms. Recombinases play a central role in this pathway: multiple protein subunits of Rad51 or its orthologues bind single-stranded DNA to form a nucleoprotein filament which is essential for initiating recombination events. Multiple factors are involved in the regulation of this step, both positively and negatively. In this review, we discuss Rad51 nucleoprotein assembly and disassembly, how it is regulated and what functional significance it has in genome maintenance.

KW - homologous recombination

KW - Rad51 filament

KW - double-stranded DNA break

KW - DNA repair

KW - Rad51 regulation

U2 - 10.15698/cst2018.05.134

DO - 10.15698/cst2018.05.134

M3 - Article

SN - 2523-0204

SP - 96

EP - 112

JO - Cell Stress

JF - Cell Stress

ER -

Putting together and taking apart: assembly and disassembly of the Rad51 nucleoprotein filament in DNA repair and genome stability

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

Access to Document

Fingerprint

Projects

Proteolysis-dependent regulation of telomerase catalytic subunit

Cite this