Putting together and taking apart: assembly and disassembly of the Rad51 nucleoprotein filament in DNA repair and genome stability

Tadas Andriuskevicius, Oleksii Kotenko, Svetlana Makovets

Research output: Contribution to journalArticlepeer-review

Abstract

Homologous recombination is a key mechanism providing both genome stability and genetic diversity in all living organisms. Recombinases play a central role in this pathway: multiple protein subunits of Rad51 or its orthologues bind single-stranded DNA to form a nucleoprotein filament which is essential for initiating recombination events. Multiple factors are involved in the regulation of this step, both positively and negatively. In this review, we discuss Rad51 nucleoprotein assembly and disassembly, how it is regulated and what functional significance it has in genome maintenance.
Original languageEnglish
Pages (from-to)96 - 112
Number of pages17
JournalCell Stress
DOIs
Publication statusPublished - 28 Mar 2018

Keywords

  • homologous recombination
  • Rad51 filament
  • double-stranded DNA break
  • DNA repair
  • Rad51 regulation

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