pzl-1 encodes a novel protein phosphatase-Z-like Ser/Thr protein phosphatase in Neurospora crassa

B Szoor, Z Feher, T Zeke, P Gergely, E Yatzkan, O Yarden, Z. Dombradi

Research output: Contribution to journalArticlepeer-review

Abstract

The gene and cDNA of a novel protein phosphatase were cloned from Neurospora crassa. The pzl-1 gene encompasses three introns and is localized to the left arm of chromosome I between cyt-21 and Fsr-12. It encodes a protein of 58.3 kDa containing a Ser/Pro rich N-terminal segment, and a C-terminal domain that is similar to the catalytic subunit of type 1 protein phosphatases. The first 51 amino acid residues, including a potential N-myristoylation site, as well as the C-terminal domain (about 300 residues) have a high level of sequence identity with yeast PPZ phosphatases. However, residues 52-208 do not share high similarity with other proteins. The mRNA of pzl-1 was detected in all phases of asexual development of the filamentous fungus. (C) 1998 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)260-266
Number of pages7
JournalBiochimica et biophysica acta-Protein structure and molecular enzymology
Volume1388
Issue number1
Publication statusPublished - 14 Oct 1998

Keywords

  • Ser/Thr protein phosphatase
  • PPZ-like protein
  • fungal development
  • (Neurospora crassa)
  • CATALYTIC SUBUNIT
  • MOLECULAR-CLONING
  • SALT TOLERANCE
  • YEAST-CELLS
  • CONSERVATION
  • MAINTENANCE
  • ISOFORMS

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