Q&A: Mesenchymal stem cells - where do they come from and is it important?

Iain R Murray; Bruno Péault

doi:10.1186/s12915-015-0212-7

Q&A: Mesenchymal stem cells - where do they come from and is it important?

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

Mesenchymal stem - or stromal - cells (MSCs) have been administered in hundreds of clinical trials for multiple indications, making them some of the most commonly used selected regenerative cells. Paradoxically, MSCs have also long remained the least characterized stem cells regarding native identity and natural function, being isolated retrospectively in long-term culture. Recent years have seen progress in our understanding of the natural history of these cells, and candidate native MSCs have been identified within fetal and adult organs. Beyond basic knowledge, deciphering the biology of innate MSCs may have important positive consequences for the therapeutic use of these cells.

Original language	English
Pages (from-to)	99
Journal	BMC Biology
Volume	13
Issue number	1
DOIs	https://doi.org/10.1186/s12915-015-0212-7
Publication status	Published - 23 Nov 2015

Access to Document

10.1186/s12915-015-0212-7

Peault B mesenchymal stem cells
© 2015 Murray and Péault. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
Final published version, 962 KBLicence: Creative Commons: Attribution (CC-BY)

Cite this

@article{2a001e6967d44ab994247c6cbbfac53e,

title = "Q&A: Mesenchymal stem cells - where do they come from and is it important?",

abstract = "Mesenchymal stem - or stromal - cells (MSCs) have been administered in hundreds of clinical trials for multiple indications, making them some of the most commonly used selected regenerative cells. Paradoxically, MSCs have also long remained the least characterized stem cells regarding native identity and natural function, being isolated retrospectively in long-term culture. Recent years have seen progress in our understanding of the natural history of these cells, and candidate native MSCs have been identified within fetal and adult organs. Beyond basic knowledge, deciphering the biology of innate MSCs may have important positive consequences for the therapeutic use of these cells.",

author = "Murray, {Iain R} and Bruno P{\'e}ault",

year = "2015",

month = nov,

day = "23",

doi = "10.1186/s12915-015-0212-7",

language = "English",

volume = "13",

pages = "99",

journal = "BMC Biology",

issn = "1741-7007",

publisher = "BioMed Central",

number = "1",

}

TY - JOUR

T1 - Q&A

T2 - Mesenchymal stem cells - where do they come from and is it important?

AU - Murray, Iain R

AU - Péault, Bruno

PY - 2015/11/23

Y1 - 2015/11/23

N2 - Mesenchymal stem - or stromal - cells (MSCs) have been administered in hundreds of clinical trials for multiple indications, making them some of the most commonly used selected regenerative cells. Paradoxically, MSCs have also long remained the least characterized stem cells regarding native identity and natural function, being isolated retrospectively in long-term culture. Recent years have seen progress in our understanding of the natural history of these cells, and candidate native MSCs have been identified within fetal and adult organs. Beyond basic knowledge, deciphering the biology of innate MSCs may have important positive consequences for the therapeutic use of these cells.

AB - Mesenchymal stem - or stromal - cells (MSCs) have been administered in hundreds of clinical trials for multiple indications, making them some of the most commonly used selected regenerative cells. Paradoxically, MSCs have also long remained the least characterized stem cells regarding native identity and natural function, being isolated retrospectively in long-term culture. Recent years have seen progress in our understanding of the natural history of these cells, and candidate native MSCs have been identified within fetal and adult organs. Beyond basic knowledge, deciphering the biology of innate MSCs may have important positive consequences for the therapeutic use of these cells.

U2 - 10.1186/s12915-015-0212-7

DO - 10.1186/s12915-015-0212-7

M3 - Literature review

C2 - 26596888

SN - 1741-7007

VL - 13

SP - 99

JO - BMC Biology

JF - BMC Biology

IS - 1

ER -

Q&A: Mesenchymal stem cells - where do they come from and is it important?

Abstract / Description of output

Access to Document

Fingerprint

Cite this