Quantification of solute-solute interactions using negligible-depletion solid-phase microextraction: Measuring the affinity of estradiol to bulk organic matter

Peta A. Neale, Beate I. Escher, Andrea I. Schaefer

Research output: Contribution to journalArticlepeer-review

Abstract

The interaction of trace organic contaminants with bulk organic matter has implications for the transport and behavior of organic trace contaminants within the aquatic environment as well as water and wastewater treatment processes. Partition coefficients (K-0M) of the steroidal trace organic contaminant estradiol were quantified for environmentally relevant concentrations of bulk organic matter (12.5 mg C/L) using a full mass balance form of solid-phase microextraction (SPME). The results indicated that the method is successful and can be used at environmental concentrations. Estradiol had the greatest affinity for bulk organic matter that contained phenolic and benzoic acid ester groups, namely tannic acid, compared to organics containing predominately carboxylic functional groups. The solution chemistry (pH) was found to influence the interaction, as estradiol had a lower affinity for negatively charged and hydrophilic bulk organic matter. The partition coefficients determined using SPME were consistent with partition coefficients derived using solubility enhancement and fluorescence quenching measurements, confirming that SPME is a powerful technique to quantify the affinity of estradiol for low concentrations of bulk organic matter and trace contaminants. Further, this novel method can be applied to a range of trace contaminants.

Original languageEnglish
Pages (from-to)2886-2892
Number of pages7
JournalEnvironmental Science and Technology
Volume42
Issue number8
DOIs
Publication statusPublished - 15 Apr 2008

Keywords

  • DETERMINE PARTITION-COEFFICIENTS
  • DISSOLVED HUMIC MATERIALS
  • MOLECULAR-WEIGHT
  • SOLUBILITY ENHANCEMENT
  • HYDROPHOBIC CHEMICALS
  • AQUATIC ENVIRONMENT
  • NATURAL ESTROGENS
  • BISPHENOL-A
  • SORPTION
  • SUBSTANCES

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