Quantitative analysis of changes in ER, PR and HER2 expression in primary breast cancer and paired nodal metastases

S J Aitken, J S Thomas, S P Langdon, D J Harrison, D Faratian

Research output: Contribution to journalArticlepeer-review

Abstract

Assessment of receptors [estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2)] is routinely carried out on primary tumour in order to select appropriate adjuvant therapy; the same analysis is not carried out on nodal metastases. Since de novo resistance to therapy is common, we quantified differences in receptor expression between primary and nodal disease in order to assess whether this might contribute to therapeutic resistance.
Original languageEnglish
Pages (from-to)1254-61
Number of pages8
JournalAnnals of Oncology
Volume21
Issue number6
DOIs
Publication statusPublished - 2010

Keywords

  • breast cancer
  • ER
  • HER2
  • image analysis
  • molecular phenotype
  • nodal metastases
  • PR

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