Quantitative measures of human immunodeficiency virus-specific antibodies predict progression to aids

Steffanie A. Strathdee*, John W. Frank, John Mc Laughlin, Michael Leblanc, Carol Major, Michael V. O′ Shaughnessy, Stanley E. Read

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Studies examining specific antibodies directed against antigenic components of human immunodeficiency virus (HIV), as potential markers of progression to AIDS, have reported inconsistent results. We used reflectance densitometry and survival analysis to determine whether single quantitative measures of HIV-specific antibodies predicted progression to AIDS in a prospective cohort of 159 HIV-infected homosexual men. Lowered baseline levels of p24 antibody and p24/gp41 antibody ratio were independent predictors of progression to AIDS and retained statistical significance after simultaneously controlling for CD4:CD8 ratio, age, use of zidovudine, and clinical symptoms. Quantitative measures of p24 antibody and p24/gp41 antibody ratio warrant further study with regards to their clinical application as markers of HIV disease progression.

Original languageEnglish
Pages (from-to)1375-1379
Number of pages5
JournalJournal of Infectious Diseases
Volume172
Issue number5
DOIs
Publication statusPublished - 1 Nov 1995

Fingerprint

Dive into the research topics of 'Quantitative measures of human immunodeficiency virus-specific antibodies predict progression to aids'. Together they form a unique fingerprint.

Cite this