Projects per year
Abstract
Participants from the Lothian Birth Cohort 1936 underwent brain MRI at mean age 73 years. Longitudinal relaxation time (T1), magnetization transfer ratio (MTR), fractional anisotropy (FA) and mean diffusivity (MD) were measured in the hippocampus. General factors of fluid-type intelligence (g), cognitive processing speed (speed) and memory were obtained at age 73 years, as well as childhood IQ test results at age 11 years. Amongst 565 older adults, multivariate linear regression showed that, after correcting for ICV, gender and age 11 IQ, larger left hippocampal volume was significantly associated with better memory ability (β = 0.11, p=0.003), but not with speed or g. Using quantitative MRI and after correcting for multiple testing, higher T1 and MD were significantly associated with lower scores of g (β range = -0.11 to -0.14, p<0.001), speed (β range = -0.15 to -0.20, p<0.001) and memory (β range = -0.10 to -0.12, p<0.001). Higher MTR and FA in the hippocampus were also significantly associated with higher scores of g (β range = 0.17 to 0.18, p<0.0001) and speed (β range = 0.10 to 0.15, p<0.0001), but not memory.
Quantitative multi-modal MRI assessments were more sensitive at detecting cognition-hippocampal integrity associations than volumetric measurements, resulting in stronger associations between MRI biomarkers and age-related cognition changes.
Original language | English |
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Pages (from-to) | 34-44 |
Number of pages | 11 |
Journal | Cortex |
Volume | 53C |
Early online date | 31 Dec 2013 |
DOIs | |
Publication status | Published - Apr 2014 |
Keywords / Materials (for Non-textual outputs)
- Longitudinal Relaxation Times
- Diffusion Tensor Imaging
- Hippocampus
- Cognition
- Ageing
- Magnetic resonance imaging
- MRI
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Dive into the research topics of 'Quantitative multi-modal MRI of the hippocampus and cognitive ability in community-dwelling older subjects'. Together they form a unique fingerprint.Projects
- 8 Finished
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Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2.
Maclullich, A. (Principal Investigator)
1/09/13 → 31/08/19
Project: Research
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RA2661 Centre for Cognitive Ageing and Cognitive Epidemiology Phase 2. Main Budget.
Deary, I. (Principal Investigator), Gale, C. (Co-investigator), Holmes, M. (Co-investigator), Logie, P. (Co-investigator), Maclullich, A. (Co-investigator), Porteous, D. (Co-investigator), Seckl, J. (Co-investigator), Starr, J. (Co-investigator), Wardlaw, J. (Co-investigator) & Okely, J. (Researcher)
1/09/13 → 31/08/19
Project: Research
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Brain White mater imaging and cognitive ageing in the Lothian Birth Cohort of 1936:II
Deary, I. (Principal Investigator), Bastin, M. (Co-investigator), Penke, L. (Co-investigator), Starr, J. (Co-investigator) & Wardlaw, J. (Co-investigator)
8/06/11 → 7/03/15
Project: Research