Quantitative multi-modal MRI of the hippocampus and cognitive ability in community-dwelling older subjects

Benjamin Aribisala, Natalie Royle, Susana Munoz-Maniega, Maria Valdes Hernandez, Catherine Murray, Lars Penke, Alan Gow, John Starr, Mark Bastin, Ian Deary, Joanna Wardlaw

Research output: Contribution to journalArticlepeer-review

Abstract

Hippocampal structural integrity is commonly quantified using volumetric measurements derived from brain magnetic resonance imaging (MRI). Previously reported associations with cognitive decline have not been consistent. We investigate hippocampal integrity using quantitative MRI techniques and its association with cognitive abilities in older age.
Participants from the Lothian Birth Cohort 1936 underwent brain MRI at mean age 73 years. Longitudinal relaxation time (T1), magnetization transfer ratio (MTR), fractional anisotropy (FA) and mean diffusivity (MD) were measured in the hippocampus. General factors of fluid-type intelligence (g), cognitive processing speed (speed) and memory were obtained at age 73 years, as well as childhood IQ test results at age 11 years. Amongst 565 older adults, multivariate linear regression showed that, after correcting for ICV, gender and age 11 IQ, larger left hippocampal volume was significantly associated with better memory ability (β = 0.11, p=0.003), but not with speed or g. Using quantitative MRI and after correcting for multiple testing, higher T1 and MD were significantly associated with lower scores of g (β range = -0.11 to -0.14, p<0.001), speed (β range = -0.15 to -0.20, p<0.001) and memory (β range = -0.10 to -0.12, p<0.001). Higher MTR and FA in the hippocampus were also significantly associated with higher scores of g (β range = 0.17 to 0.18, p<0.0001) and speed (β range = 0.10 to 0.15, p<0.0001), but not memory.
Quantitative multi-modal MRI assessments were more sensitive at detecting cognition-hippocampal integrity associations than volumetric measurements, resulting in stronger associations between MRI biomarkers and age-related cognition changes.
Original languageEnglish
Pages (from-to)34-44
Number of pages11
JournalCortex
Volume53C
Early online date31 Dec 2013
DOIs
Publication statusPublished - Apr 2014

Keywords

  • Longitudinal Relaxation Times
  • Diffusion Tensor Imaging
  • Hippocampus
  • Cognition
  • Ageing
  • Magnetic resonance imaging
  • MRI

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