Quantitative trait Loci for health traits in Finnish Ayrshire cattle

N F Schulman, S M Viitala, D J de Koning, J Virta, A Mäki-Tanila, J H Vilkki

Research output: Contribution to journalArticlepeer-review

Abstract

A whole-genome scan was conducted to search for quantitative trait loci (QTL) affecting health traits in Finnish Ayrshire dairy cattle. The mapping population consisted of 12 bulls and their 491 sons in a granddaughter design. A total of 150 markers were typed covering all 29 autosomes. The traits under study were somatic cell score, mastitis, and a group of other veterinary treatments. Effects of the QTL and positions were estimated with the regression method. When carrying out interval mapping on each chromosome, cofactors were used to adjust for QTL identified at other chromosomes. Empirical P-values were obtained by permutation. Altogether 17 QTL were detected with genomewise significant P-values in the across family analysis. Quantitative trait loci affecting SCS were identified on chromosomes 1, 3, 11, 18, 21, 24, 27, 29, and QTL for mastitis on chromosomes 14, 18. Quantitative trait loci for other veterinary treatments were found on chromosomes 1, 2, 5, 8, 15, 22, and 23. The allele substitution effects were from 0.5 to 1.7 genetic standard deviations. The positions of these health QTL did not overlap with milk QTL detected in previous studies of the same population.
Original languageEnglish
Pages (from-to)443-9
Number of pages7
JournalJournal of Dairy Science
Volume87
Issue number2
DOIs
Publication statusPublished - Feb 2004

Keywords

  • Animals
  • Cattle
  • Cell Count
  • Chromosome Mapping
  • Female
  • Health Status
  • Male
  • Mastitis, Bovine
  • Milk
  • Quantitative Trait Loci
  • Regression Analysis

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