Projects per year
Abstract
BACKGROUND: Canine hip dysplasia (CHD) is characterised by a malformation of the hip joint, leading to osteoarthritis and lameness. Current breeding schemes against CHD have resulted in measurable but moderate responses. The application of marker-assisted selection, incorporating specific markers associated with the disease, or genomic selection, incorporating genome-wide markers, has the potential to dramatically improve results of breeding schemes. Our aims were to identify regions associated with hip dysplasia or its related traits using genome and chromosome-wide analysis, study the linkage disequilibrium (LD) in these regions and provide plausible gene candidates. This study is focused on the UK Labrador Retriever population, which has a high prevalence of the disease and participates in a recording program led by the British Veterinary Association (BVA) and The Kennel Club (KC).
RESULTS: Two genome-wide and several chromosome-wide QTLs affecting CHD and its related traits were identified, indicating regions related to hip dysplasia.
CONCLUSION: Consistent with previous studies, the genetic architecture of CHD appears to be based on many genes with small or moderate effect, suggesting that genomic selection rather than marker-assisted selection may be an appropriate strategy for reducing this disease.
Original language | English |
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Pages (from-to) | 833 |
Journal | BMC Genomics |
Volume | 15 |
Issue number | 1 |
DOIs | |
Publication status | Published - 1 Oct 2014 |
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Dive into the research topics of 'Quantitative trait loci mapping for canine hip dysplasia and its related traits in UK Labrador Retrievers'. Together they form a unique fingerprint.Projects
- 3 Finished
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Future-Proofing the sustainability of the MRC high throughput sequencing hub in Scotland
Blaxter, M.
1/10/12 → 30/09/14
Project: Research
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