Quantitative trait loci variation for growth and obesity between and within lines of pigs (Sus scrofa)

Yoshitaka Nagamine, Asheber Sewalem, Peter M Visscher, Chris Haley

Research output: Contribution to journalArticlepeer-review

Abstract

The hypothesis that quantitative trait loci (QTL) that explain variation between divergent populations also account for genetic variation within populations was tested using pig populations. Two regions of the porcine genome that had previously been reported to harbor QTL with allelic effects that differed between the modern pig and its wild-type ancestor and between the modern pig and a more distantly related population of Asian pigs were studied. QTL for growth and obesity traits were mapped using selectively genotyped half-sib families from five domesticated modern populations. Strong support was found for at least one QTL segregating in each population. For all five populations there was evidence of a segregating QTL affecting fatness in a region on chromosome 7. These findings confirm that QTL can be detected in highly selected commercial populations and are consistent with the hypothesis that the same chromosome locations that account for variation between populations also explain genetic variation within populations.
Original languageEnglish
Pages (from-to)629-35
Number of pages7
JournalGenetics
Volume164
Issue number2
Publication statusPublished - 2003

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