Quantum dots decorated with pathogen associated molecular patterns as fluorescent synthetic pathogen models

Tom A. Barr, Martin Krembuszewski, Manish Gupta, David Gray, Juan C. Mareque-Rivas

Research output: Contribution to journalArticlepeer-review

Abstract

We attached the pathogen associated molecular pattern Kdo(2)-Lipid A (the lipopolysaccharide (LPS) from Escherichia coli (E. coli)) to QDs by hydrophobic interactions to synthetically mimic the surface of E. coli. QD-LPS conjugates bind, are taken up and activate effectively macrophages in vitro and they have potent immunostimulatory activity in vivo.

Original languageEnglish
Pages (from-to)1568-1571
Number of pages4
JournalMolecular BioSystems
Volume6
Issue number9
DOIs
Publication statusPublished - 2010

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