Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway

G P Hubbard, J M Stevens, M Cicmil, T Sage, P A Jordan, C M Williams, J A Lovegrove, J M Gibbins

Research output: Contribution to journalArticlepeer-review

Abstract

The regulation of platelet function by pharmacological agents that modulate platelet signaling has proven a successful approach to the prevention of thrombosis. A variety of molecules present in the diet have been shown to inhibit platelet activation, including the antioxidant quercetin.
Original languageEnglish
Pages (from-to)1079-88
Number of pages10
JournalJournal of Thrombosis and Haemostasis
Volume1
Issue number5
DOIs
Publication statusPublished - May 2003

Keywords

  • Antioxidants
  • Calcium
  • Collagen
  • Dose-Response Relationship, Drug
  • Humans
  • Phosphorylation
  • Platelet Activation
  • Platelet Aggregation
  • Platelet Membrane Glycoproteins
  • Protein-Tyrosine Kinases
  • Quercetin
  • Signal Transduction
  • Tyrosine

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