Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway

G P Hubbard; J M Stevens; M Cicmil; T Sage; P A Jordan; C M Williams; J A Lovegrove; J M Gibbins

doi:10.1046/j.1538-7836.2003.00212.x

Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway

G P Hubbard, J M Stevens, M Cicmil, T Sage, P A Jordan, C M Williams, J A Lovegrove, J M Gibbins

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

The regulation of platelet function by pharmacological agents that modulate platelet signaling has proven a successful approach to the prevention of thrombosis. A variety of molecules present in the diet have been shown to inhibit platelet activation, including the antioxidant quercetin.

Original language	English
Pages (from-to)	1079-88
Number of pages	10
Journal	Journal of Thrombosis and Haemostasis
Volume	1
Issue number	5
DOIs	https://doi.org/10.1046/j.1538-7836.2003.00212.x
Publication status	Published - May 2003

Keywords

Antioxidants
Calcium
Collagen
Dose-Response Relationship, Drug
Humans
Phosphorylation
Platelet Activation
Platelet Aggregation
Platelet Membrane Glycoproteins
Protein-Tyrosine Kinases
Quercetin
Signal Transduction
Tyrosine

Access to Document

10.1046/j.1538-7836.2003.00212.x

Quercetin inhibits collagen-stimulated platelet activation
Copyright 2003 International Society on Thrombosis and Haemostasis
Final published version, 291 KB

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Hubbard, G. P., Stevens, J. M., Cicmil, M., Sage, T., Jordan, P. A., Williams, C. M., Lovegrove, J. A., & Gibbins, J. M. (2003). Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway. Journal of Thrombosis and Haemostasis, 1(5), 1079-88. https://doi.org/10.1046/j.1538-7836.2003.00212.x

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abstract = "The regulation of platelet function by pharmacological agents that modulate platelet signaling has proven a successful approach to the prevention of thrombosis. A variety of molecules present in the diet have been shown to inhibit platelet activation, including the antioxidant quercetin.",

keywords = "Antioxidants, Calcium, Collagen, Dose-Response Relationship, Drug, Humans, Phosphorylation, Platelet Activation, Platelet Aggregation, Platelet Membrane Glycoproteins, Protein-Tyrosine Kinases, Quercetin, Signal Transduction, Tyrosine",

author = "Hubbard, {G P} and Stevens, {J M} and M Cicmil and T Sage and Jordan, {P A} and Williams, {C M} and Lovegrove, {J A} and Gibbins, {J M}",

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Quercetin inhibits collagen-stimulated platelet activation through inhibition of multiple components of the glycoprotein VI signaling pathway. / Hubbard, G P; Stevens, J M; Cicmil, M; Sage, T; Jordan, P A; Williams, C M; Lovegrove, J A; Gibbins, J M.

In: Journal of Thrombosis and Haemostasis, Vol. 1, No. 5, 05.2003, p. 1079-88.

Research output: Contribution to journal › Article › peer-review

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AU - Cicmil, M

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AU - Jordan, P A

AU - Williams, C M

AU - Lovegrove, J A

AU - Gibbins, J M

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KW - Calcium

KW - Collagen

KW - Dose-Response Relationship, Drug

KW - Humans

KW - Phosphorylation

KW - Platelet Activation

KW - Platelet Aggregation

KW - Platelet Membrane Glycoproteins

KW - Protein-Tyrosine Kinases

KW - Quercetin

KW - Signal Transduction

KW - Tyrosine

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DO - 10.1046/j.1538-7836.2003.00212.x

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