Abstract
In the presence of diethylzinc as a stoichiometric reductant, substoichiometric quantities of an appropriate cobalt source catalyse diastereoselective reductive aldol coupling reactions of alpha,beta-unsaturated amides with ketones. The use of a readily available oxazolidine as a chiral auxiliary imparts high levels of asymmetric induction in these reactions. (C) 2008 Elsevier Ltd. All rights reserved.
Original language | English |
---|---|
Pages (from-to) | 7729-7740 |
Number of pages | 12 |
Journal | Tetrahedron |
Volume | 64 |
Issue number | 33 |
DOIs | |
Publication status | Published - 11 Aug 2008 |
Keywords / Materials (for Non-textual outputs)
- KETENE SILYL ACETAL
- CHIRAL LEWIS-ACIDS
- ENANTIOSELECTIVE SYNTHESIS
- PYRUVATE ESTERS
- STEREOSELECTIVE-SYNTHESIS
- STOICHIOMETRIC REDUCTANT
- COPPER(II) COMPLEXES
- CONJUGATE ADDITION
- CARBONYL-COMPOUNDS
- ENOL ETHER