RADSeq: next-generation population genetics

John L Davey, Mark W Blaxter

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Next-generation sequencing technologies are making a substantial impact on many areas of biology, including the analysis of genetic diversity in populations. However, genome-scale population genetic studies have been accessible only to well-funded model systems. Restriction-site associated DNA sequencing, a method that samples at reduced complexity across target genomes, promises to deliver high resolution population genomic data-thousands of sequenced markers across many individuals-for any organism at reasonable costs. It has found application in wild populations and non-traditional study species, and promises to become an important technology for ecological population genomics.
Original languageEnglish
Pages (from-to)416-23
Number of pages8
JournalBriefings in functional genomics
Volume9
Issue number5-6
DOIs
Publication statusPublished - Dec 2010

Keywords / Materials (for Non-textual outputs)

  • Animals
  • Base Sequence
  • Genetic Variation
  • Genetics, Population
  • Genome
  • Humans
  • Phylogeny
  • Polymorphism, Single Nucleotide
  • Restriction Mapping
  • Sequence Analysis, DNA

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