Raman Microscopy and Associated Techniques for Label-Free Imaging of Cancer Tissue

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Raman spectroscopy can identify cancerous from healthy tissue, with a chemical analysis from the measurement of vibrational bond frequencies. However, to detect small tumors a form of Raman imaging is required. Such imaging—by acquiring a Raman spectrum at each imaging pixel—can detect tumors but is rather slow. Multiphoton versions of Raman—anti-Stokes Raman scattering (CARS) microscopy and stimulated Raman scattering (SRS) microscopy—offer similar accuracies in identifying cancerous tissue and tumor margins but with a far higher speed, which is beneficial for diagnosis of small tumors in tissue. SRS microscopy can also be used to image extrinsic molecules in living cells, such as anti-cancer drugs at typical concentrations.
Original languageEnglish
Pages (from-to)641-653
Number of pages13
JournalApplied Spectroscopy Reviews
Volume50
Issue number8
DOIs
Publication statusPublished - 14 Sept 2015

Keywords / Materials (for Non-textual outputs)

  • Raman spectroscopy
  • CANCER

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