Random blood glucose measurement at antenatal booking to screen for overt diabetes in pregnancy: a retrospective study

David Church, David Halsall, Claire Meek, Richard A Parker, Helen R Murphy, David Simmons

Research output: Contribution to journalArticlepeer-review

Abstract

OBJECTIVE: To assess random venous blood glucose (RBG) measurement at antenatal booking to detect "overt diabetes in pregnancy" (ODIP).

RESEARCH DESIGN AND METHODS: A retrospective analysis of regional hospital obstetric data from 2004-2008 was performed. Universal RBG screening was included at booking. Oral glucose tolerance test (OGTT) was administered if RBG >7.0 mmol/L or other indications, e.g., if a 50-g glucose challenge test was >7.7 mmol/L at 26-28 weeks. ODIP was based upon World Health Organization plasma glucose criteria for diabetes.

RESULTS: RBG data were collected from 17,852/26,369 (67.7%) pregnancies around the initial antenatal visit; 3,007 women had an OGTT. The receiver operator curve area under the curve for RBG to detect ODIP was 0.86 (0.80-0.92) (assuming women without an OGTT did not have ODIP).

CONCLUSIONS: RBG at booking may provide a sufficiently sensitive screening tool for the detection of ODIP. We recommend further studies and comparison with fasting glucose and HbA(1c).

Original languageEnglish
Pages (from-to)2217-9
Number of pages3
JournalDiabetes Care
Volume34
Issue number10
DOIs
Publication statusPublished - Oct 2011

Keywords

  • Adolescent
  • Adult
  • Blood Glucose
  • Diabetes Mellitus
  • Female
  • Glucose Tolerance Test
  • Humans
  • Middle Aged
  • Pregnancy
  • Retrospective Studies
  • Young Adult

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