Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy

A J Thomson; C B Lunan; M Ledingham; R C Howat; I T Cameron; I A Greer; J E Norman

doi:10.1016/S0140-6736(98)01289-6

Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy

A J Thomson, C B Lunan, M Ledingham, R C Howat, I T Cameron, I A Greer, J E Norman

Deanery of Clinical Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Vaginal administration of the nitric oxide donor isosorbide mononitrate can induce effective ripening of the human cervix. We investigated whether this drug is associated with fewer side-effects than prostaglandins when used to ripen the cervix before first-trimester surgical termination of pregnancy, and assessed whether the extent of cervical ripening it induces is clinically sufficient.

Original language	English
Pages (from-to)	1093-6
Number of pages	4
Journal	The Lancet
Volume	352
Issue number	9134
DOIs	https://doi.org/10.1016/S0140-6736(98)01289-6
Publication status	Published - 1998

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10.1016/S0140-6736(98)01289-6

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title = "Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy",

abstract = "Vaginal administration of the nitric oxide donor isosorbide mononitrate can induce effective ripening of the human cervix. We investigated whether this drug is associated with fewer side-effects than prostaglandins when used to ripen the cervix before first-trimester surgical termination of pregnancy, and assessed whether the extent of cervical ripening it induces is clinically sufficient.",

author = "Thomson, {A J} and Lunan, {C B} and M Ledingham and Howat, {R C} and Cameron, {I T} and Greer, {I A} and Norman, {J E}",

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T1 - Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy

AU - Thomson, A J

AU - Lunan, C B

AU - Ledingham, M

AU - Howat, R C

AU - Cameron, I T

AU - Greer, I A

AU - Norman, J E

PY - 1998

Y1 - 1998

N2 - Vaginal administration of the nitric oxide donor isosorbide mononitrate can induce effective ripening of the human cervix. We investigated whether this drug is associated with fewer side-effects than prostaglandins when used to ripen the cervix before first-trimester surgical termination of pregnancy, and assessed whether the extent of cervical ripening it induces is clinically sufficient.

AB - Vaginal administration of the nitric oxide donor isosorbide mononitrate can induce effective ripening of the human cervix. We investigated whether this drug is associated with fewer side-effects than prostaglandins when used to ripen the cervix before first-trimester surgical termination of pregnancy, and assessed whether the extent of cervical ripening it induces is clinically sufficient.

U2 - 10.1016/S0140-6736(98)01289-6

DO - 10.1016/S0140-6736(98)01289-6

M3 - Article

C2 - 9798584

SN - 0140-6736

VL - 352

SP - 1093

EP - 1096

JO - The Lancet

JF - The Lancet

IS - 9134

ER -

Randomised trial of nitric oxide donor versus prostaglandin for cervical ripening before first-trimester termination of pregnancy

Abstract

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