Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial

Robert E Mansel; Lesley Fallowfield; Mark Kissin; Amit Goyal; Robert G Newcombe; J Michael Dixon; Constantinos Yiangou; Kieran Horgan; Nigel Bundred; Ian Monypenny; David England; Mark Sibbering; Tholkifl I Abdullah; Lester Barr; Utheshtra Chetty; Dudley H Sinnett; Anne Fleissig; Dayalan Clarke; Peter J Ell

doi:10.1093/jnci/djj158

Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial

Robert E Mansel, Lesley Fallowfield, Mark Kissin, Amit Goyal, Robert G Newcombe, J Michael Dixon, Constantinos Yiangou, Kieran Horgan, Nigel Bundred, Ian Monypenny, David England, Mark Sibbering, Tholkifl I Abdullah, Lester Barr, Utheshtra Chetty, Dudley H Sinnett, Anne Fleissig, Dayalan Clarke, Peter J Ell

Deanery of Molecular, Genetic and Population Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Sentinel lymph node biopsy in women with operable breast cancer is routinely used in some countries for staging the axilla despite limited data from randomized trials on morbidity and mortality outcomes. We conducted a multicenter randomized trial to compare quality-of-life outcomes between patients with clinically node-negative invasive breast cancer who received sentinel lymph node biopsy and patients who received standard axillary treatment.

Original language	English
Pages (from-to)	599-609
Number of pages	11
Journal	JNCI: Journal of the National Cancer Institute
Volume	98
Issue number	9
DOIs	https://doi.org/10.1093/jnci/djj158
Publication status	Published - 3 May 2006

Keywords

Arm
Axilla
Breast Neoplasms
Breast Neoplasms, Male
Carcinoma, Ductal, Breast
Carcinoma, Lobular
Drainage
Female
Humans
Incidence
Length of Stay
Lymph Node Excision
Lymphatic Metastasis
Lymphedema
Male
Mastectomy
Middle Aged
Movement
Quality of Life
Radiotherapy, Adjuvant
Risk Assessment
Sentinel Lymph Node Biopsy
Shoulder
Surgical Wound Infection
Treatment Outcome

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10.1093/jnci/djj158

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Mansel, R. E., Fallowfield, L., Kissin, M., Goyal, A., Newcombe, R. G., Dixon, J. M., Yiangou, C., Horgan, K., Bundred, N., Monypenny, I., England, D., Sibbering, M., Abdullah, T. I., Barr, L., Chetty, U., Sinnett, D. H., Fleissig, A., Clarke, D., & Ell, P. J. (2006). Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial. JNCI: Journal of the National Cancer Institute, 98(9), 599-609. https://doi.org/10.1093/jnci/djj158

Mansel, Robert E ; Fallowfield, Lesley ; Kissin, Mark ; Goyal, Amit ; Newcombe, Robert G ; Dixon, J Michael ; Yiangou, Constantinos ; Horgan, Kieran ; Bundred, Nigel ; Monypenny, Ian ; England, David ; Sibbering, Mark ; Abdullah, Tholkifl I ; Barr, Lester ; Chetty, Utheshtra ; Sinnett, Dudley H ; Fleissig, Anne ; Clarke, Dayalan ; Ell, Peter J. / Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer : the ALMANAC Trial. In: JNCI: Journal of the National Cancer Institute. 2006 ; Vol. 98, No. 9. pp. 599-609.

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title = "Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial",

abstract = "Sentinel lymph node biopsy in women with operable breast cancer is routinely used in some countries for staging the axilla despite limited data from randomized trials on morbidity and mortality outcomes. We conducted a multicenter randomized trial to compare quality-of-life outcomes between patients with clinically node-negative invasive breast cancer who received sentinel lymph node biopsy and patients who received standard axillary treatment.",

keywords = "Arm, Axilla, Breast Neoplasms, Breast Neoplasms, Male, Carcinoma, Ductal, Breast, Carcinoma, Lobular, Drainage, Female, Humans, Incidence, Length of Stay, Lymph Node Excision, Lymphatic Metastasis, Lymphedema, Male, Mastectomy, Middle Aged, Movement, Quality of Life, Radiotherapy, Adjuvant, Risk Assessment, Sentinel Lymph Node Biopsy, Shoulder, Surgical Wound Infection, Treatment Outcome",

author = "Mansel, {Robert E} and Lesley Fallowfield and Mark Kissin and Amit Goyal and Newcombe, {Robert G} and Dixon, {J Michael} and Constantinos Yiangou and Kieran Horgan and Nigel Bundred and Ian Monypenny and David England and Mark Sibbering and Abdullah, {Tholkifl I} and Lester Barr and Utheshtra Chetty and Sinnett, {Dudley H} and Anne Fleissig and Dayalan Clarke and Ell, {Peter J}",

year = "2006",

month = may,

day = "3",

doi = "10.1093/jnci/djj158",

language = "English",

volume = "98",

pages = "599--609",

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Mansel, RE, Fallowfield, L, Kissin, M, Goyal, A, Newcombe, RG, Dixon, JM, Yiangou, C, Horgan, K, Bundred, N, Monypenny, I, England, D, Sibbering, M, Abdullah, TI, Barr, L, Chetty, U, Sinnett, DH, Fleissig, A, Clarke, D & Ell, PJ 2006, 'Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial', JNCI: Journal of the National Cancer Institute, vol. 98, no. 9, pp. 599-609. https://doi.org/10.1093/jnci/djj158

Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer : the ALMANAC Trial. / Mansel, Robert E; Fallowfield, Lesley; Kissin, Mark; Goyal, Amit; Newcombe, Robert G; Dixon, J Michael; Yiangou, Constantinos; Horgan, Kieran; Bundred, Nigel; Monypenny, Ian; England, David; Sibbering, Mark; Abdullah, Tholkifl I; Barr, Lester; Chetty, Utheshtra; Sinnett, Dudley H; Fleissig, Anne; Clarke, Dayalan; Ell, Peter J.

In: JNCI: Journal of the National Cancer Institute, Vol. 98, No. 9, 03.05.2006, p. 599-609.

Research output: Contribution to journal › Article › peer-review

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T1 - Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer

T2 - the ALMANAC Trial

AU - Mansel, Robert E

AU - Fallowfield, Lesley

AU - Kissin, Mark

AU - Goyal, Amit

AU - Newcombe, Robert G

AU - Dixon, J Michael

AU - Yiangou, Constantinos

AU - Horgan, Kieran

AU - Bundred, Nigel

AU - Monypenny, Ian

AU - England, David

AU - Sibbering, Mark

AU - Abdullah, Tholkifl I

AU - Barr, Lester

AU - Chetty, Utheshtra

AU - Sinnett, Dudley H

AU - Fleissig, Anne

AU - Clarke, Dayalan

AU - Ell, Peter J

PY - 2006/5/3

Y1 - 2006/5/3

N2 - Sentinel lymph node biopsy in women with operable breast cancer is routinely used in some countries for staging the axilla despite limited data from randomized trials on morbidity and mortality outcomes. We conducted a multicenter randomized trial to compare quality-of-life outcomes between patients with clinically node-negative invasive breast cancer who received sentinel lymph node biopsy and patients who received standard axillary treatment.

AB - Sentinel lymph node biopsy in women with operable breast cancer is routinely used in some countries for staging the axilla despite limited data from randomized trials on morbidity and mortality outcomes. We conducted a multicenter randomized trial to compare quality-of-life outcomes between patients with clinically node-negative invasive breast cancer who received sentinel lymph node biopsy and patients who received standard axillary treatment.

KW - Arm

KW - Axilla

KW - Breast Neoplasms

KW - Breast Neoplasms, Male

KW - Carcinoma, Ductal, Breast

KW - Carcinoma, Lobular

KW - Drainage

KW - Female

KW - Humans

KW - Incidence

KW - Length of Stay

KW - Lymph Node Excision

KW - Lymphatic Metastasis

KW - Lymphedema

KW - Male

KW - Mastectomy

KW - Middle Aged

KW - Movement

KW - Quality of Life

KW - Radiotherapy, Adjuvant

KW - Risk Assessment

KW - Sentinel Lymph Node Biopsy

KW - Shoulder

KW - Surgical Wound Infection

KW - Treatment Outcome

U2 - 10.1093/jnci/djj158

DO - 10.1093/jnci/djj158

M3 - Article

C2 - 16670385

VL - 98

SP - 599

EP - 609

JO - JNCI: Journal of the National Cancer Institute

JF - JNCI: Journal of the National Cancer Institute

SN - 0027-8874

IS - 9

ER -

Randomized multicenter trial of sentinel node biopsy versus standard axillary treatment in operable breast cancer: the ALMANAC Trial

Abstract

Keywords

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