Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli

D A Hume, M R Thornton, M J Weidemann, V Speth

Research output: Contribution to journalArticlepeer-review

Abstract

Under conditions where a maximum stimulation of 3-O-methyl-glucose transport is observed, three thymocyte mitogens (concanavalin A, ionophore A23187 and hydrogen peroxide) cause cell rounding and a decrease in the density of intra-membrane particles on the plasma membrane. The early effects of mitogens on the thymocyte plasma membrane are similar to those of osmotic shock.
Original languageEnglish
Pages (from-to)523-8
Number of pages6
JournalJournal of Cellular Physiology
Volume101
Issue number3
DOIs
Publication statusPublished - Dec 1979

Keywords

  • Animals
  • Calcimycin
  • Cell Membrane
  • Concanavalin A
  • Hydrogen Peroxide
  • Lymphocyte Activation
  • Male
  • Methylglucosides
  • Microscopy, Electron, Scanning
  • Mitogens
  • Osmotic Pressure
  • Rats
  • T-Lymphocytes

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