Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli

D A Hume; M R Thornton; M J Weidemann; V Speth

doi:10.1002/jcp.1041010318

Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli

D A Hume, M R Thornton, M J Weidemann, V Speth

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Under conditions where a maximum stimulation of 3-O-methyl-glucose transport is observed, three thymocyte mitogens (concanavalin A, ionophore A23187 and hydrogen peroxide) cause cell rounding and a decrease in the density of intra-membrane particles on the plasma membrane. The early effects of mitogens on the thymocyte plasma membrane are similar to those of osmotic shock.

Original language	English
Pages (from-to)	523-8
Number of pages	6
Journal	Journal of Cellular Physiology
Volume	101
Issue number	3
DOIs	https://doi.org/10.1002/jcp.1041010318
Publication status	Published - Dec 1979

Keywords / Materials (for Non-textual outputs)

Animals
Calcimycin
Cell Membrane
Concanavalin A
Hydrogen Peroxide
Lymphocyte Activation
Male
Methylglucosides
Microscopy, Electron, Scanning
Mitogens
Osmotic Pressure
Rats
T-Lymphocytes

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10.1002/jcp.1041010318

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title = "Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli",

abstract = "Under conditions where a maximum stimulation of 3-O-methyl-glucose transport is observed, three thymocyte mitogens (concanavalin A, ionophore A23187 and hydrogen peroxide) cause cell rounding and a decrease in the density of intra-membrane particles on the plasma membrane. The early effects of mitogens on the thymocyte plasma membrane are similar to those of osmotic shock.",

keywords = "Animals, Calcimycin, Cell Membrane, Concanavalin A, Hydrogen Peroxide, Lymphocyte Activation, Male, Methylglucosides, Microscopy, Electron, Scanning, Mitogens, Osmotic Pressure, Rats, T-Lymphocytes",

author = "Hume, {D A} and Thornton, {M R} and Weidemann, {M J} and V Speth",

year = "1979",

month = dec,

doi = "10.1002/jcp.1041010318",

language = "English",

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pages = "523--8",

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issn = "0021-9541",

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TY - JOUR

T1 - Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli

AU - Hume, D A

AU - Thornton, M R

AU - Weidemann, M J

AU - Speth, V

PY - 1979/12

Y1 - 1979/12

N2 - Under conditions where a maximum stimulation of 3-O-methyl-glucose transport is observed, three thymocyte mitogens (concanavalin A, ionophore A23187 and hydrogen peroxide) cause cell rounding and a decrease in the density of intra-membrane particles on the plasma membrane. The early effects of mitogens on the thymocyte plasma membrane are similar to those of osmotic shock.

AB - Under conditions where a maximum stimulation of 3-O-methyl-glucose transport is observed, three thymocyte mitogens (concanavalin A, ionophore A23187 and hydrogen peroxide) cause cell rounding and a decrease in the density of intra-membrane particles on the plasma membrane. The early effects of mitogens on the thymocyte plasma membrane are similar to those of osmotic shock.

KW - Animals

KW - Calcimycin

KW - Cell Membrane

KW - Concanavalin A

KW - Hydrogen Peroxide

KW - Lymphocyte Activation

KW - Male

KW - Methylglucosides

KW - Microscopy, Electron, Scanning

KW - Mitogens

KW - Osmotic Pressure

KW - Rats

KW - T-Lymphocytes

U2 - 10.1002/jcp.1041010318

DO - 10.1002/jcp.1041010318

M3 - Article

C2 - 118973

SN - 0021-9541

VL - 101

SP - 523

EP - 528

JO - Journal of Cellular Physiology

JF - Journal of Cellular Physiology

IS - 3

ER -

Rapid alterations in cellular morphology and plasma membrane structure induced in rat thymocytes by mitogenic stimuli

Abstract

Keywords / Materials (for Non-textual outputs)

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