Rapid kinetics to peak serum antibodies is achieved following influenza vaccination by dry-coated densely packed microprojections to skin

Xianfeng Chen, Germain J.P. Fernando, Anthony P. Raphael, Sally R. Yukiko, Emily J. Fairmaid, Clare A. Primiero, Ian H. Frazer, Lorena E. Brown, Mark A.F. Kendall*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

A rapid time to peak serum antibody response following vaccination is particularly important for influenza: the time window between the availability of appropriate antigen and the start of the seasonal epidemic is very short. In this paper, influenza vaccine was delivered to both the epidermis and dermis of mouse skin using densely packed microprojection arrays for vaccination. We found that, after vaccination, around 75% and 90% of the delivered influenza vaccine migrated away from the ear skin within just 2 days and 1 week - respectively. And the time to peak serum antibody response was as early as 2 weeks. This result matches the kinetics achieved by intramuscular injection of liquid vaccine to muscle. Thus, we demonstrate that skin delivery of small vaccine volumes discretely by thousands of densely packed microprojections neither induces delay in kinetics nor interferes with the long-lasting antibody response; compared to conventional intramuscular injection.

Original languageEnglish
Pages (from-to)78-84
Number of pages7
JournalJournal of Controlled Release
Volume158
Issue number1
DOIs
Publication statusPublished - 28 Feb 2012

Keywords

  • Microneedles
  • Microprojections
  • Needle-free vaccination
  • Skin delivery

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