Rapid, quantitative, and site specific synthesis of biomolecular radicals from a simple photocaged precursor

Tony Ly; Xing Zhang; Qingyu Sun; Benjamin Moore; Yuanqi Tao; Ryan R. Julian

doi:10.1039/c0cc03363d

Rapid, quantitative, and site specific synthesis of biomolecular radicals from a simple photocaged precursor

Tony Ly, Xing Zhang, Qingyu Sun, Benjamin Moore, Yuanqi Tao, Ryan R. Julian^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Novel p-iodobenzoate-based labelling reagents are shown to be effective photocaged precursors for synthesizing biomolecular radicals site-selectively in the gaseous and condensed phases. In vacuo, a single pulse of UV photons (266 nm) is sufficient to quantitatively photolyse the C-I bond. In aqueous solutions, the photolysis half-life is estimated to be 2.5 minutes when irradiating with a 15 W compact fluorescent lamp (254 nm).

Original language	English
Pages (from-to)	2835-2837
Number of pages	3
Journal	Chemical Communications
Volume	47
Issue number	10
Early online date	24 Jan 2011
DOIs	https://doi.org/10.1039/c0cc03363d
Publication status	Published - 14 Mar 2011

Keywords

GAS-PHASE
DIRECTED DISSOCIATION
RIBONUCLEOTIDE REDUCTASE
ELECTROSPRAY-IONIZATION
PEPTIDE
GENERATION
PROTEINS
ION
TRYPTOPHAN
PHOTOLYSIS

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title = "Rapid, quantitative, and site specific synthesis of biomolecular radicals from a simple photocaged precursor",

abstract = "Novel p-iodobenzoate-based labelling reagents are shown to be effective photocaged precursors for synthesizing biomolecular radicals site-selectively in the gaseous and condensed phases. In vacuo, a single pulse of UV photons (266 nm) is sufficient to quantitatively photolyse the C-I bond. In aqueous solutions, the photolysis half-life is estimated to be 2.5 minutes when irradiating with a 15 W compact fluorescent lamp (254 nm).",

keywords = "GAS-PHASE, DIRECTED DISSOCIATION, RIBONUCLEOTIDE REDUCTASE, ELECTROSPRAY-IONIZATION, PEPTIDE, GENERATION, PROTEINS, ION, TRYPTOPHAN, PHOTOLYSIS",

author = "Tony Ly and Xing Zhang and Qingyu Sun and Benjamin Moore and Yuanqi Tao and Julian, {Ryan R.}",

year = "2011",

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day = "14",

doi = "10.1039/c0cc03363d",

language = "English",

volume = "47",

pages = "2835--2837",

journal = "Chemical Communications",

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TY - JOUR

T1 - Rapid, quantitative, and site specific synthesis of biomolecular radicals from a simple photocaged precursor

AU - Ly, Tony

AU - Zhang, Xing

AU - Sun, Qingyu

AU - Moore, Benjamin

AU - Tao, Yuanqi

AU - Julian, Ryan R.

PY - 2011/3/14

Y1 - 2011/3/14

N2 - Novel p-iodobenzoate-based labelling reagents are shown to be effective photocaged precursors for synthesizing biomolecular radicals site-selectively in the gaseous and condensed phases. In vacuo, a single pulse of UV photons (266 nm) is sufficient to quantitatively photolyse the C-I bond. In aqueous solutions, the photolysis half-life is estimated to be 2.5 minutes when irradiating with a 15 W compact fluorescent lamp (254 nm).

AB - Novel p-iodobenzoate-based labelling reagents are shown to be effective photocaged precursors for synthesizing biomolecular radicals site-selectively in the gaseous and condensed phases. In vacuo, a single pulse of UV photons (266 nm) is sufficient to quantitatively photolyse the C-I bond. In aqueous solutions, the photolysis half-life is estimated to be 2.5 minutes when irradiating with a 15 W compact fluorescent lamp (254 nm).

KW - GAS-PHASE

KW - DIRECTED DISSOCIATION

KW - RIBONUCLEOTIDE REDUCTASE

KW - ELECTROSPRAY-IONIZATION

KW - PEPTIDE

KW - GENERATION

KW - PROTEINS

KW - ION

KW - TRYPTOPHAN

KW - PHOTOLYSIS

U2 - 10.1039/c0cc03363d

DO - 10.1039/c0cc03363d

M3 - Article

VL - 47

SP - 2835

EP - 2837

JO - Chemical Communications

JF - Chemical Communications

SN - 1359-7345

IS - 10

ER -

Rapid, quantitative, and site specific synthesis of biomolecular radicals from a simple photocaged precursor

Abstract

Keywords

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