Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients

Liane M McGlynn; Tove Kirkegaard; Joanne Edwards; Sian Tovey; David Cameron; Chris Twelves; John M S Bartlett; Timothy G Cooke

doi:10.1158/1078-0432.CCR-07-4967

Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients

Liane M McGlynn, Tove Kirkegaard, Joanne Edwards, Sian Tovey, David Cameron, Chris Twelves, John M S Bartlett, Timothy G Cooke

Research output: Contribution to journal › Article › peer-review

Abstract

The expression and activation of the Ras/Raf-1/mitogen-activated protein kinase (MAPK) pathway plays an important role in the development and progression of cancer, and may influence response to treatments such as tamoxifen and chemotherapy. In this study we investigated whether the expression and activation of the key components of this pathway influenced clinical outcome, to test the hypothesis that activation of the MAPK pathway drives resistance to tamoxifen and chemotherapy in women with breast cancer.

Original language	English
Pages (from-to)	1487-95
Number of pages	9
Journal	Clinical Cancer Research
Volume	15
Issue number	4
DOIs	https://doi.org/10.1158/1078-0432.CCR-07-4967
Publication status	Published - 2009

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abstract = "The expression and activation of the Ras/Raf-1/mitogen-activated protein kinase (MAPK) pathway plays an important role in the development and progression of cancer, and may influence response to treatments such as tamoxifen and chemotherapy. In this study we investigated whether the expression and activation of the key components of this pathway influenced clinical outcome, to test the hypothesis that activation of the MAPK pathway drives resistance to tamoxifen and chemotherapy in women with breast cancer.",

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AU - McGlynn, Liane M

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AU - Edwards, Joanne

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AU - Cameron, David

AU - Twelves, Chris

AU - Bartlett, John M S

AU - Cooke, Timothy G

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AB - The expression and activation of the Ras/Raf-1/mitogen-activated protein kinase (MAPK) pathway plays an important role in the development and progression of cancer, and may influence response to treatments such as tamoxifen and chemotherapy. In this study we investigated whether the expression and activation of the key components of this pathway influenced clinical outcome, to test the hypothesis that activation of the MAPK pathway drives resistance to tamoxifen and chemotherapy in women with breast cancer.

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Ras/Raf-1/MAPK pathway mediates response to tamoxifen but not chemotherapy in breast cancer patients

Abstract

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