Projects per year
Abstract / Description of output
Method: MRI brain scans of members of the Lothian Birth Cohort 1936 (LBC1936) were assessed to obtain measures of the volume and severity of white matter hyperintensities, and the integrity of brain white matter tracts. CRT was assessed with a four choice reaction time task on a separate occasion. Data were analysed using multiple regression (range N = 358 to 670). Results: Greater volume of hyperintensities and more severe hyperintensities in frontal regions were associated with higher CRT IIV. White matter tract integrity, as assessed by both fractional anisotropy and mean diffusivity, was not significantly associated with CRT IIV. Associations with hyperintensities were attenuated and no longer significant after controlling for mean CRT. Conclusions: Taken together, the results of the present study suggested that IIV was not incrementally predictive of white matter integrity over mean speed. This is in contrast to previous reports, and highlights the need for further study.
Keywords / Materials (for Non-textual outputs)
- white matter hyperintensities
- diffusion tensor imaging,
- reaction time
- intra-individual variability
- cognitive ageing
FingerprintDive into the research topics of 'Reaction time variability and brain white matter integrity'. Together they form a unique fingerprint.
- 3 Finished
Wardlaw, J. & Atkinson, M.
1/02/08 → 31/12/14
Person: Academic: Research Active