Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor

Jamie Marland; Mark Gray; Camelia Dunare; Ewen Blair; Andreas Tsiamis; Paul Sullivan; Eva González-Fernández; Stephen Greenhalgh; Rachael Gregson; Eddie Clutton; Magdalena Parys; Alex Dyson; Mervyn Singer; Ian Kunkler; Mark A Potter; Srinjoy Mitra; Jonathan Terry; Stewart Smith; Andrew Mount; Ian Underwood; Anthony Walton; David Argyle; Alan Murray

doi:10.1016/j.sbsr.2020.100375

Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor

Jamie Marland, Mark Gray, Camelia Dunare, Ewen Blair, Andreas Tsiamis, Paul Sullivan, Eva González-Fernández, Stephen Greenhalgh, Rachael Gregson, Eddie Clutton, Magdalena Parys, Alex Dyson, Mervyn Singer, Ian Kunkler, Mark A Potter, Srinjoy Mitra, Jonathan Terry, Stewart Smith, Andrew Mount, Ian UnderwoodAnthony Walton, David Argyle, Alan Murray

Research output: Contribution to journal › Article › peer-review

Abstract

Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating and selectively increasing the dose delivered to hypoxic regions. Here we describe a miniature implantable sensor for real-time monitoring of tissue oxygenation that could enable this novel treatment approach to be implemented. The sensor uses a solid-state electrochemical cell that was microfabricated at wafer level on a silicon substrate, and includes an integrated reference electrode and electrolyte membrane. It gave a linear response to oxygen concentration, and was unaffected by sterilisation and irradiation, but showed susceptibility to biofouling. Oxygen selectivity was also evaluated against various clinically relevant electroactive compounds. We investigated its robustness and functionality under realistic clinical conditions using a sheep model of lung cancer. The sensor remained functional following CT-guided tumour implantation, and was sufficiently sensitive to track acute changes in oxygenation within tumour tissue.

Original language	English
Article number	100375
Pages (from-to)	1-12
Number of pages	12
Journal	Sensing and Bio-Sensing Research
Volume	30
Early online date	11 Aug 2020
DOIs	https://doi.org/10.1016/j.sbsr.2020.100375
Publication status	E-pub ahead of print - 11 Aug 2020

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10.1016/j.sbsr.2020.100375

Marland_et_al_2020Accepted author manuscript, 6.37 MBLicence: Unspecified
1-s2.0-S2214180420301409-mainFinal published version, 2.98 MBLicence: Creative Commons: Attribution (CC-BY)

Implantable Microsystems for Personalised Anti-Cancer Therapy
Murray, A. (Principal Investigator), Smith, S. (Co-investigator) & Walton, A. (Co-investigator)
EPSRC
27/05/13 → 31/05/19
Project: Research

Dataset for "Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor"
Marland, J. (Creator), Gray, E. (Creator), Dunare, C. (Creator), Blair, E. (Creator), Tsiamis, A. (Creator), Sullivan, P. (Creator), González-Fernández, E. (Creator), Greenhalgh, S. (Creator), Gregson, R. (Creator), Clutton, R. (Creator), Parys, M. (Creator), Dyson, A. (Creator), Singer, M. (Creator), Kunkler, I. (Creator), Potter, M. A. (Creator), Mitra, S. (Creator), Terry, J. (Creator), Smith, S. (Creator), Mount, A. (Creator), Underwood, I. (Creator), Walton, A. (Creator), Argyle, D. (Creator) & Murray, A. (Creator), Edinburgh DataShare, 26 Oct 2020
DOI: 10.7488/ds/2544
Dataset

David Argyle
- College of Medicine and Veterinary Medicine - Vice Principal and Head of College of Medicine & Veterinary
Person: Academic: Research Active
Mark Gray
- Royal (Dick) School of Veterinary Studies - Senior Lecturer
Person: Academic: Research Active
Ian Underwood
- School of Engineering - Chair of Electronic Displays
Person: Academic: Research Active

Cite this

Marland, J., Gray, M., Dunare, C., Blair, E., Tsiamis, A., Sullivan, P., González-Fernández, E., Greenhalgh, S., Gregson, R., Clutton, E., Parys, M., Dyson, A., Singer, M., Kunkler, I., Potter, M. A., Mitra, S., Terry, J., Smith, S., Mount, A., ... Murray, A. (2020). Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor. Sensing and Bio-Sensing Research, 30, 1-12. Article 100375. Advance online publication. https://doi.org/10.1016/j.sbsr.2020.100375

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title = "Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor",

abstract = "Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating and selectively increasing the dose delivered to hypoxic regions. Here we describe a miniature implantable sensor for real-time monitoring of tissue oxygenation that could enable this novel treatment approach to be implemented. The sensor uses a solid-state electrochemical cell that was microfabricated at wafer level on a silicon substrate, and includes an integrated reference electrode and electrolyte membrane. It gave a linear response to oxygen concentration, and was unaffected by sterilisation and irradiation, but showed susceptibility to biofouling. Oxygen selectivity was also evaluated against various clinically relevant electroactive compounds. We investigated its robustness and functionality under realistic clinical conditions using a sheep model of lung cancer. The sensor remained functional following CT-guided tumour implantation, and was sufficiently sensitive to track acute changes in oxygenation within tumour tissue.",

author = "Jamie Marland and Mark Gray and Camelia Dunare and Ewen Blair and Andreas Tsiamis and Paul Sullivan and Eva Gonz{\'a}lez-Fern{\'a}ndez and Stephen Greenhalgh and Rachael Gregson and Eddie Clutton and Magdalena Parys and Alex Dyson and Mervyn Singer and Ian Kunkler and Potter, {Mark A} and Srinjoy Mitra and Jonathan Terry and Stewart Smith and Andrew Mount and Ian Underwood and Anthony Walton and David Argyle and Alan Murray",

year = "2020",

month = aug,

day = "11",

doi = "10.1016/j.sbsr.2020.100375",

language = "English",

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journal = "Sensing and Bio-Sensing Research",

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Marland, J , Gray, M, Dunare, C, Blair, E, Tsiamis, A, Sullivan, P, González-Fernández, E, Greenhalgh, S , Gregson, R , Clutton, E , Parys, M, Dyson, A, Singer, M, Kunkler, I, Potter, MA, Mitra, S , Terry, J , Smith, S , Mount, A , Underwood, I, Walton, A, Argyle, D & Murray, A 2020, 'Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor', Sensing and Bio-Sensing Research, vol. 30, 100375, pp. 1-12. https://doi.org/10.1016/j.sbsr.2020.100375

TY - JOUR

T1 - Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor

AU - Marland, Jamie

AU - Gray, Mark

AU - Dunare, Camelia

AU - Blair, Ewen

AU - Tsiamis, Andreas

AU - Sullivan, Paul

AU - González-Fernández, Eva

AU - Greenhalgh, Stephen

AU - Gregson, Rachael

AU - Clutton, Eddie

AU - Parys, Magdalena

AU - Dyson, Alex

AU - Singer, Mervyn

AU - Kunkler, Ian

AU - Potter, Mark A

AU - Mitra, Srinjoy

AU - Terry, Jonathan

AU - Smith, Stewart

AU - Mount, Andrew

AU - Underwood, Ian

AU - Walton, Anthony

AU - Argyle, David

AU - Murray, Alan

PY - 2020/8/11

Y1 - 2020/8/11

N2 - Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating and selectively increasing the dose delivered to hypoxic regions. Here we describe a miniature implantable sensor for real-time monitoring of tissue oxygenation that could enable this novel treatment approach to be implemented. The sensor uses a solid-state electrochemical cell that was microfabricated at wafer level on a silicon substrate, and includes an integrated reference electrode and electrolyte membrane. It gave a linear response to oxygen concentration, and was unaffected by sterilisation and irradiation, but showed susceptibility to biofouling. Oxygen selectivity was also evaluated against various clinically relevant electroactive compounds. We investigated its robustness and functionality under realistic clinical conditions using a sheep model of lung cancer. The sensor remained functional following CT-guided tumour implantation, and was sufficiently sensitive to track acute changes in oxygenation within tumour tissue.

AB - Hypoxia commonly occurs within tumours and is a major cause of radiotherapy resistance. Clinical outcomes could be improved by locating and selectively increasing the dose delivered to hypoxic regions. Here we describe a miniature implantable sensor for real-time monitoring of tissue oxygenation that could enable this novel treatment approach to be implemented. The sensor uses a solid-state electrochemical cell that was microfabricated at wafer level on a silicon substrate, and includes an integrated reference electrode and electrolyte membrane. It gave a linear response to oxygen concentration, and was unaffected by sterilisation and irradiation, but showed susceptibility to biofouling. Oxygen selectivity was also evaluated against various clinically relevant electroactive compounds. We investigated its robustness and functionality under realistic clinical conditions using a sheep model of lung cancer. The sensor remained functional following CT-guided tumour implantation, and was sufficiently sensitive to track acute changes in oxygenation within tumour tissue.

U2 - 10.1016/j.sbsr.2020.100375

DO - 10.1016/j.sbsr.2020.100375

M3 - Article

SN - 2214-1804

VL - 30

SP - 1

EP - 12

JO - Sensing and Bio-Sensing Research

JF - Sensing and Bio-Sensing Research

M1 - 100375

ER -

Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor

Abstract

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Implantable Microsystems for Personalised Anti-Cancer Therapy

Datasets

Dataset for "Real-time measurement of tumour hypoxia using an implantable microfabricated oxygen sensor"

Profiles

David Argyle

Mark Gray

Ian Underwood

Cite this