Reassortment patterns of avian influenza virus internal segments among different subtypes

Research output: Contribution to journalArticlepeer-review

Abstract

The segmented RNA genome of avian Influenza viruses (AIV) allows genetic reassortment between co-infecting viruses, providing an evolutionary pathway to generate genetic innovation. The genetic diversity (16 haemagglutinin and 9 neuraminidase subtypes) of AIV indicates an extensive reservoir of influenza viruses exists in bird populations, but how frequently subtypes reassort with each other is still unknown. Here we quantify the reassortment patterns among subtypes in the Eurasian avian viral pool by reconstructing the ancestral states of the subtypes as discrete states on time-scaled phylogenies with respect to the internal protein coding segments. We further analyzed how host species, the inferred evolutionary rates and the dN/dS ratio varied among segments and between discrete subtypes, and whether these factors may be associated with inter-subtype reassortment rate.
Original languageEnglish
Article number16
Number of pages15
JournalBMC Evolutionary Biology
Volume14
Issue number1
DOIs
Publication statusPublished - 24 Jan 2014

Keywords

  • Influenza
  • Monte Carlo Markov chain
  • Avian Influenza Virus
  • Wild Bird

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