Recent advances in developing neuroprotective strategies for perinatal asphyxia

N J Robertson; A D Edwards

doi:10.1097/00008480-199810060-00006

Recent advances in developing neuroprotective strategies for perinatal asphyxia

N J Robertson, A D Edwards

Research output: Contribution to journal › Review article › peer-review

Abstract / Description of output

Perinatal asphyxia is the most important cause of acute neurologic injury in the newborn and occurs in approximately six per 1000 term live births. After resuscitation of an infant with birth asphyxia, the emphasis has been on supportive therapy; however, there is increasing evidence that a "therapeutic window" exists in the early hours following the insult, and perhaps for longer, when intervention can attenuate activation of the neurotoxic cascade that leads to delayed cell death hours, days or months later.

Original language	English
Pages (from-to)	575-80
Number of pages	6
Journal	Current opinion in pediatrics
Volume	10
Issue number	6
DOIs	https://doi.org/10.1097/00008480-199810060-00006
Publication status	Published - Dec 1998

Keywords / Materials (for Non-textual outputs)

Asphyxia Neonatorum/complications
Brain Injuries/etiology
Cell Death
Humans
Infant, Newborn
Neuroprotective Agents/therapeutic use
Resuscitation/methods
Time Factors

Access to Document

10.1097/00008480-199810060-00006

Cite this

@article{b04ee9daac5e451d8b5f5c82c82cc3f3,

title = "Recent advances in developing neuroprotective strategies for perinatal asphyxia",

abstract = "Perinatal asphyxia is the most important cause of acute neurologic injury in the newborn and occurs in approximately six per 1000 term live births. After resuscitation of an infant with birth asphyxia, the emphasis has been on supportive therapy; however, there is increasing evidence that a {"}therapeutic window{"} exists in the early hours following the insult, and perhaps for longer, when intervention can attenuate activation of the neurotoxic cascade that leads to delayed cell death hours, days or months later.",

keywords = "Asphyxia Neonatorum/complications, Brain Injuries/etiology, Cell Death, Humans, Infant, Newborn, Neuroprotective Agents/therapeutic use, Resuscitation/methods, Time Factors",

author = "Robertson, {N J} and Edwards, {A D}",

year = "1998",

month = dec,

doi = "10.1097/00008480-199810060-00006",

language = "English",

volume = "10",

pages = "575--80",

journal = "Current opinion in pediatrics",

issn = "1040-8703",

publisher = "Lippincott Williams and Wilkins Ltd.",

number = "6",

}

TY - JOUR

T1 - Recent advances in developing neuroprotective strategies for perinatal asphyxia

AU - Robertson, N J

AU - Edwards, A D

PY - 1998/12

Y1 - 1998/12

N2 - Perinatal asphyxia is the most important cause of acute neurologic injury in the newborn and occurs in approximately six per 1000 term live births. After resuscitation of an infant with birth asphyxia, the emphasis has been on supportive therapy; however, there is increasing evidence that a "therapeutic window" exists in the early hours following the insult, and perhaps for longer, when intervention can attenuate activation of the neurotoxic cascade that leads to delayed cell death hours, days or months later.

AB - Perinatal asphyxia is the most important cause of acute neurologic injury in the newborn and occurs in approximately six per 1000 term live births. After resuscitation of an infant with birth asphyxia, the emphasis has been on supportive therapy; however, there is increasing evidence that a "therapeutic window" exists in the early hours following the insult, and perhaps for longer, when intervention can attenuate activation of the neurotoxic cascade that leads to delayed cell death hours, days or months later.

KW - Asphyxia Neonatorum/complications

KW - Brain Injuries/etiology

KW - Cell Death

KW - Humans

KW - Infant, Newborn

KW - Neuroprotective Agents/therapeutic use

KW - Resuscitation/methods

KW - Time Factors

U2 - 10.1097/00008480-199810060-00006

DO - 10.1097/00008480-199810060-00006

M3 - Review article

C2 - 9848015

SN - 1040-8703

VL - 10

SP - 575

EP - 580

JO - Current opinion in pediatrics

JF - Current opinion in pediatrics

IS - 6

ER -

Recent advances in developing neuroprotective strategies for perinatal asphyxia

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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Cite this