Recent Advances in Pathology: the 2021 Annual Review Issue of The Journal of Path

C Simon Herrington, Richard Poulsom, Hartmut Koeppen, Philip J Coates

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The 2021 Annual Review Issue of The Journal of Pathology contains 14 invited reviews on current research areas of particular importance in pathology. The subjects included here reflect the broad range of interests covered by the journal, including both basic and applied research fields but always with the aim of improving our understanding of human disease. This year, our reviews encompass the huge impact of the COVID-19 pandemic, the development and application of biomarkers for immune checkpoint inhibitors, recent advances in multiplexing antigen/nucleic acid detection in situ, the use of genomics to aid drug discovery, organoid methodologies in research, the microbiome in cancer, the role of macrophage-stroma interactions in fibrosis, and TGF-β as a driver
of fibrosis in multiple pathologies. Other reviews revisit the p53 field and its lack of clinical impact to date, dissect
the genetics of mitochondrial diseases, summarise the cells of origin and genetics of sarcomagenesis, provide
new data on the role of TRIM28 in tumour predisposition, review our current understanding of cancer stem cell
niches, and the function and regulation of p63. The reviews are authored by experts in their field from academia
and industry, and provide comprehensive updates of the chosen areas, in which there has been considerable recent

Original languageEnglish
JournalJournal of Pathology
Early online date7 Jun 2021
Publication statusE-pub ahead of print - 7 Jun 2021

Keywords / Materials (for Non-textual outputs)

  • 3D culture
  • acute resiparatory distress syndrome (ARDS)
  • angiotensin-converting enzyme 2 (ACE2);
  • antifibrotic
  • atezolizumab
  • autoimmunity
  • bone
  • cancer
  • cancer predisposition
  • cancer progression
  • cancer stem cells (CSCs)
  • cell of origin
  • cellular crosstalk
  • chromatin modification
  • coronavirus diseas 2019 (COVID-19)
  • CSC niche
  • dysbiosis
  • damage-associated molecular patterns
  • epithelial to mesenchymal transition (EMT)
  • endothelial to mesenchymal transition (endMT)
  • epigenetics
  • extracellular matrix
  • gene enhancers
  • genetic diagnosis
  • genetics
  • genomics
  • GWAS
  • HDAC inhibitors
  • human genetics
  • ioiopathic pulmonary birosis
  • IL-33
  • immuno-oncology
  • mmunopathology
  • immunotherapy
  • inflmamation
  • intratumoral microbiota
  • imilimumab
  • KAP1
  • local microbiota
  • macrophages
  • MAPK
  • MDM2
  • metabolomics
  • microbial metabolites
  • microbial toxins
  • microbiome
  • mitochondrial disease
  • mitochondrial pathology
  • mTOR
  • microstructure
  • migration
  • mouse model
  • multiplex immunohistochemistry
  • multiplex in situe hybridization
  • oncogene
  • nephroblastoma
  • nivolumab
  • organoids
  • p53
  • p63
  • pathology
  • pathophysiology
  • PD01
  • PD-L1
  • pembrolizumab
  • phagocytosis
  • polarization
  • polygenic risk score
  • precision medicine
  • profibrotic
  • proteomics
  • sarcome
  • severe actute reisparatory syndrome coronovirus 2 (SARS-CoV-2)
  • shear stress
  • single cell transcriptomes
  • Smad
  • soft tissue
  • spatial transcriptomics
  • squamous cell cancer
  • stem cells
  • stiffness
  • stretch
  • TGF-B
  • therapeutic discovery
  • therapy
  • TIF1beta
  • treatment
  • TRIM28
  • tumorigenesis
  • tumour-infiltrating lymphocytes
  • tumour microenviroment
  • tumour suppressor
  • Wilms' tumour


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