Recent Advances in Pathology: the 2022 Annual Review Issue of The Journal of Pathology

C Simon Herrington, Richard Poulsom, Nischalan Pillay, Peter Bankhead, Philip J Coates

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The 2022 Annual Review Issue of The Journal of Pathology, Recent Advances in Pathology, contains 15 invited reviews on research areas of growing importance in pathology. This year, the articles include those that focus on digital pathology, employing modern imaging techniques and software to enable improved diagnostic and research applications to study human diseases. This
subject area includes the ability to identify specific genetic alterations through the morphological changes they induce, as well as integrating digital and computational pathology with ‘omics technologies. Other reviews in this issue include an updated evaluation of mutational patterns (mutation signatures) in cancer, the applications of lineage tracing in human tissues, and single cell sequencing technologies to uncover tumour evolution and tumour heterogeneity. The tissue microenvironment is covered in reviews specifically dealing with proteolytic control of epidermal differentiation, cancer associated fibroblasts, field cancerisation, and host factors that determine tumour immunity. All of the reviews contained in this issue are the work of invited experts selected to discuss the considerable recent progress in their respective fields and are freely available online (
Original languageEnglish
JournalThe Journal of Pathology
Early online date30 May 2022
Publication statusE-pub ahead of print - 30 May 2022

Keywords / Materials (for Non-textual outputs)

  • 3D reconstruction
  • adult stem cells
  • artificial intelligence
  • sthma
  • biomarkers
  • breast cancer
  • cancer
  • cancer-adjacent tissues
  • cancer-associated fibroblasts
  • chromothripsis
  • chronice obstructive pulmonary disease
  • clonal dynamics
  • clonality analysis
  • colon
  • computational pathology
  • convolutional neural networks
  • copy number aberrations
  • copy number signatures
  • cystic fibrosis
  • data repository
  • desquamation
  • digical pathology
  • DNA sequencing
  • epidermal imflammation
  • epidermis
  • epithelial transition states
  • extrachromosomal DNA
  • field cancerisation
  • filaggrin
  • functional pathology
  • genomics
  • haemopoietic stem cells
  • ost
  • idiopathic pulmonary fibrosis
  • image anaysis
  • image processing
  • immune checkpoint inhibitors
  • immune system
  • immunotherapy
  • in situ hybridisation
  • intestinal stem cells
  • intra-tumour heterogeneity
  • in vivo models
  • lineage tracing
  • lung atlas
  • lung diseases
  • lung progenitors
  • lung stem cells
  • kallikrein-elatedpeptidases
  • macine learning
  • metabolome
  • mirobiome
  • mutational signatures
  • open science
  • PAR1
  • PAR2
  • paient stratification
  • prediction
  • prognosis
  • proease inhibitors
  • proteolytic cascades
  • quantitative mehtods
  • QuPath
  • single cel DNA sequencing
  • single cell RNA sequencing
  • single-cell transcriptomics
  • skin diseases
  • skin physiology
  • software
  • structurcal variants
  • subclone
  • tumour evolution
  • tumur phylogeny
  • virtual slide
  • whole-slide imaging
  • whole-slide scanning
  • whole genome sequencing


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