Recent advances in the use of stimulated Raman scattering in histopathology

Martin Lee, C Simon Herrington, Manasa Ravindra, Kristel Sepp, Amy Davies, Alison N Hulme, Valerie G Brunton

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Stimulated Raman histopathology (SRH) utilises the intrinsic vibrational properties of lipids, proteins and nucleic acids to generate contrast providing rapid image acquisition that allows visualisation of histopathological features. It is currently being trialled in the intraoperative setting, where the ability to image unprocessed samples rapidly and with high resolution offers several potential advantages over the use of conventional haematoxylin and eosin stained images. Here we review recent advances in the field including new updates in instrumentation and computer aided diagnosis. We also discuss how other non-linear modalities can be used to provide additional diagnostic contrast which together pave the way for enhanced histopathology and open up possibilities for in vivo pathology.
Original languageEnglish
Early online date4 Jan 2021
Publication statusE-pub ahead of print - 4 Jan 2021


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