Recent advances, opportunities and challenges in cybergenetic identification and control of biomolecular networks

Gianpio Caringella; Lucia Bandiera; Filippo Menolascina

doi:10.1016/j.copbio.2023.102893

Recent advances, opportunities and challenges in cybergenetic identification and control of biomolecular networks

Gianpio Caringella, Lucia Bandiera, Filippo Menolascina

Research output: Contribution to journal › Article › peer-review

Abstract

Cybergenetics is a new area of research aimed at developing digital and biological controllers for living systems. Synthetic biologists have begun exploiting cybergenetic tools and platforms to both accelerate the development of mathematical models and develop control strategies for complex biological phenomena. Here we review the state of the art in cybergenetic identification and control. Our aim is to lower the entry barrier to this field and foster the adoption of methods and technologies that will accelerate the pace at which Synthetic Biology progresses towards applications.

Original language	English
Pages (from-to)	102893
Journal	Current opinion in biotechnology
Volume	80
Early online date	25 Jan 2023
DOIs	https://doi.org/10.1016/j.copbio.2023.102893
Publication status	Published - 1 Apr 2023

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10.1016/j.copbio.2023.102893Licence: CC BY

Caringella_et_al_AFPRM (002)Accepted author manuscript, 1.05 MBLicence: Creative Commons: Attribution (CC-BY)

https://linkinghub.elsevier.com/retrieve/pii/S0958166923000034Licence: Creative Commons: Attribution (CC-BY)

21EBTA Engineering Biology for Cell and Gene Therapy Applications
Rosser, S. (Principal Investigator), Calvert, J. (Co-investigator), Cobb, S. (Co-investigator), Davies, J. (Co-investigator), Menolascina, F. (Co-investigator), Pollard, S. (Co-investigator) & Stracquadanio, G. (Co-investigator)
Biotechnology and Biological Sciences Research Council
31/01/22 → 30/01/24
Project: Research
McSynC: in vivo automatic Model calibration of Synthetic Circuits components
Menolascina, F. (Principal Investigator)
EPSRC
1/11/18 → 31/10/20
Project: Research
An intelligent approach to the automatic characterisation and design of synthetic promoters in mammalian cells
Menolascina, F. (Principal Investigator)
EPSRC
29/06/18 → 28/03/22
Project: Research

Cite this

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abstract = "Cybergenetics is a new area of research aimed at developing digital and biological controllers for living systems. Synthetic biologists have begun exploiting cybergenetic tools and platforms to both accelerate the development of mathematical models and develop control strategies for complex biological phenomena. Here we review the state of the art in cybergenetic identification and control. Our aim is to lower the entry barrier to this field and foster the adoption of methods and technologies that will accelerate the pace at which Synthetic Biology progresses towards applications.",

author = "Gianpio Caringella and Lucia Bandiera and Filippo Menolascina",

note = "Funding Information: Funding: This work was supported by the Wellcome-University of Edinburgh Institutional Strategic Support Fund [grant number 204804/Z/16/Z ] and an EPSRC Postdoctoral Fellowship [grant number EP/P017134/1-CONDSYC ] awarded to L.B.; an EPSRC Innovation Fellowship [grant number EP/S001921/1 ], an EPSRC New Investigator Award [grant number EP/R035350/1 ] and a UKRI Engineering Biology Transition Award [grant number BB/W014610/1 ] awarded to F.M. Publisher Copyright: {\textcopyright} 2023 The Author(s)",

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N2 - Cybergenetics is a new area of research aimed at developing digital and biological controllers for living systems. Synthetic biologists have begun exploiting cybergenetic tools and platforms to both accelerate the development of mathematical models and develop control strategies for complex biological phenomena. Here we review the state of the art in cybergenetic identification and control. Our aim is to lower the entry barrier to this field and foster the adoption of methods and technologies that will accelerate the pace at which Synthetic Biology progresses towards applications.

AB - Cybergenetics is a new area of research aimed at developing digital and biological controllers for living systems. Synthetic biologists have begun exploiting cybergenetic tools and platforms to both accelerate the development of mathematical models and develop control strategies for complex biological phenomena. Here we review the state of the art in cybergenetic identification and control. Our aim is to lower the entry barrier to this field and foster the adoption of methods and technologies that will accelerate the pace at which Synthetic Biology progresses towards applications.

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DO - 10.1016/j.copbio.2023.102893

M3 - Article

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VL - 80

SP - 102893

JO - Current opinion in biotechnology

JF - Current opinion in biotechnology

ER -

Recent advances, opportunities and challenges in cybergenetic identification and control of biomolecular networks

Abstract

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Projects

21EBTA Engineering Biology for Cell and Gene Therapy Applications

McSynC: in vivo automatic Model calibration of Synthetic Circuits components

An intelligent approach to the automatic characterisation and design of synthetic promoters in mammalian cells

Cite this