Reciprocal cross-protection induced by sporozoite antigens SPAG-1 from Theileria annulata and p67 from Theileria parva

F. R. Hall, N R Boulter, C. G. Duncan Brown, G Wilkie, E Kirvar, V Nene, A J Musoke, S P Morzaria, E J Glass

Research output: Contribution to journalArticlepeer-review

Abstract

Theileria annulata and Theileria parva both possess a major surface antigen on the sporozoite stage of the life-cycle, called SPAG-1 and p67, respectively. In each case, these antigens are vaccine candidates and have been shown to induce a degree of homologous protection in earlier work. These antigens share sequence homology and are serologically cross-reactive. Here, we confirm that these antigens confer protection against homologous species challenge. More importantly, they mutually confer a degree of cross-species protection raising the prospect of a common vaccine in the future.
Original languageEnglish
Pages (from-to)223-30
Number of pages8
JournalParasite Immunology
Volume22
Issue number5
DOIs
Publication statusPublished - May 2000

Keywords

  • Animals
  • Antibodies, Protozoan
  • Antigens, Protozoan
  • Cattle
  • Immunization Schedule
  • Protozoan Proteins
  • Protozoan Vaccines
  • Recombinant Proteins
  • Theileria annulata
  • Theileria parva
  • Theileriasis
  • Vaccine
  • Parasite

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