Reciprocal regulation of 11β-HSDs may predict steroid sensitivity in childhood nephrotic syndrome

Shuji Sai, Masaki Yamamoto Yamamoto, Rie Yamaguchi, Karen Chapman, Teruaki Hongo

Research output: Contribution to journalArticlepeer-review

Abstract

Childhood nephrotic syndrome (NS), in which steroid-dependence occurs concurrently with steroid-resistance, requires aggressive therapy to prevent relapse. Predictive biomarkers that can be used to stratify treatment are urgently needed. Here we report that reciprocal regulation of the glucocorticoid metabolizing enzymes, 11β-hydroxysteroid dehydrogenase (11β-HSD) types 1 and 2 is associated with steroid-responsiveness and disease remission in
childhood NS, potentially providing a marker to identify patients in which aggressive therapy
is required.
Original languageEnglish
JournalPediatrics
Volume138
Issue number3
Early online date9 Aug 2016
DOIs
Publication statusPublished - Sep 2016

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