Abstract
Childhood nephrotic syndrome (NS), in which steroid-dependence occurs concurrently with steroid-resistance, requires aggressive therapy to prevent relapse. Predictive biomarkers that can be used to stratify treatment are urgently needed. Here we report that reciprocal regulation of the glucocorticoid metabolizing enzymes, 11β-hydroxysteroid dehydrogenase (11β-HSD) types 1 and 2 is associated with steroid-responsiveness and disease remission in
childhood NS, potentially providing a marker to identify patients in which aggressive therapy
is required.
childhood NS, potentially providing a marker to identify patients in which aggressive therapy
is required.
Original language | English |
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Journal | Pediatrics |
Volume | 138 |
Issue number | 3 |
Early online date | 9 Aug 2016 |
DOIs | |
Publication status | Published - Sept 2016 |