Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood ALL

Shuji Sai; Cristina Esteves; Val Kelly; Kimiyoshi Sakaguchi; Rachel McAndrew; Sandra Chudleigh; Alison Spence; Brenda Gibson; Angela Thomas; Karen Chapman

doi:10.1016/j.jpeds.2019.12.054

Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood ALL

Shuji Sai, Cristina Esteves, Val Kelly, Kimiyoshi Sakaguchi, Rachel McAndrew, Sandra Chudleigh, Alison Spence, Brenda Gibson, Angela Thomas, Karen Chapman

Research output: Contribution to journal › Article › peer-review

Abstract

There are few biomarkers to predict efficacy of glucocorticoid treatment in childhood acute lymphoblastic leukemia (ALL) at diagnosis. Here, we demonstrate reciprocal regulation of 11beta-hydroxysteroid dehydrogenase (11b-HSD), may predict the apoptotic response of ALL to glucocorticoid treatment. Our data may be useful to refine glucocorticoid treatment, to retain benefit while minimizing side effects.(J Pediatr 2020;220:249-53).

Original language	English
Pages (from-to)	249-253
Journal	The Journal of pediatrics
Volume	220
Early online date	24 Jan 2020
DOIs	https://doi.org/10.1016/j.jpeds.2019.12.054
Publication status	Published - May 2020

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10.1016/j.jpeds.2019.12.054

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Cristina Esteves
- Cristina.Estevesroslin.ed.acuk
- Royal (Dick) School of Veterinary Studies - Core Scientist (Research Fellow)
Person: Academic: Research Active (Research Assistant)

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title = "Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood ALL",

abstract = "There are few biomarkers to predict efficacy of glucocorticoid treatment in childhood acute lymphoblastic leukemia (ALL) at diagnosis. Here, we demonstrate reciprocal regulation of 11beta-hydroxysteroid dehydrogenase (11b-HSD), may predict the apoptotic response of ALL to glucocorticoid treatment. Our data may be useful to refine glucocorticoid treatment, to retain benefit while minimizing side effects.(J Pediatr 2020;220:249-53).",

author = "Shuji Sai and Cristina Esteves and Val Kelly and Kimiyoshi Sakaguchi and Rachel McAndrew and Sandra Chudleigh and Alison Spence and Brenda Gibson and Angela Thomas and Karen Chapman",

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language = "English",

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journal = "The Journal of pediatrics",

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T1 - Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood ALL

AU - Sai, Shuji

AU - Esteves, Cristina

AU - Kelly, Val

AU - Sakaguchi, Kimiyoshi

AU - McAndrew, Rachel

AU - Chudleigh, Sandra

AU - Spence, Alison

AU - Gibson, Brenda

AU - Thomas, Angela

AU - Chapman, Karen

PY - 2020/5

Y1 - 2020/5

N2 - There are few biomarkers to predict efficacy of glucocorticoid treatment in childhood acute lymphoblastic leukemia (ALL) at diagnosis. Here, we demonstrate reciprocal regulation of 11beta-hydroxysteroid dehydrogenase (11b-HSD), may predict the apoptotic response of ALL to glucocorticoid treatment. Our data may be useful to refine glucocorticoid treatment, to retain benefit while minimizing side effects.(J Pediatr 2020;220:249-53).

AB - There are few biomarkers to predict efficacy of glucocorticoid treatment in childhood acute lymphoblastic leukemia (ALL) at diagnosis. Here, we demonstrate reciprocal regulation of 11beta-hydroxysteroid dehydrogenase (11b-HSD), may predict the apoptotic response of ALL to glucocorticoid treatment. Our data may be useful to refine glucocorticoid treatment, to retain benefit while minimizing side effects.(J Pediatr 2020;220:249-53).

U2 - 10.1016/j.jpeds.2019.12.054

DO - 10.1016/j.jpeds.2019.12.054

M3 - Article

VL - 220

SP - 249

EP - 253

JO - The Journal of pediatrics

JF - The Journal of pediatrics

SN - 0022-3476

ER -

Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood ALL

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Cristina Esteves

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