Reciprocal Regulation of HSD11B1 and HSD11B2 Predicts Glucocorticoid Sensitivity in Childhood ALL

Shuji Sai, Cristina Esteves, Val Kelly, Kimiyoshi Sakaguchi, Rachel McAndrew, Sandra Chudleigh, Alison Spence, Brenda Gibson, Angela Thomas, Karen Chapman

Research output: Contribution to journalArticlepeer-review

Abstract

There are few biomarkers to predict efficacy of glucocorticoid treatment in childhood acute lymphoblastic leukemia (ALL) at diagnosis. Here, we demonstrate reciprocal regulation of 11beta-hydroxysteroid dehydrogenase (11b-HSD), may predict the apoptotic response of ALL to glucocorticoid treatment. Our data may be useful to refine glucocorticoid treatment, to retain benefit while minimizing side effects.(J Pediatr 2020;220:249-53).
Original languageEnglish
Pages (from-to)249-253
JournalThe Journal of pediatrics
Volume220
Early online date24 Jan 2020
DOIs
Publication statusPublished - May 2020

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