Projects per year
Isolated lymphoid follicles (ILF) develop post-birth in the small and large intestines (SI and LI) and represent a dynamic response of the gut immune system to the microbiota. Despite their similarities, ILF development in the SI and LI differs on a number of levels. We show that unlike ILF in the SI, the microbiota inhibits ILF development as conventionalisation of germ-free mice reduced colonic ILF. From this, we identified a novel mechanism regulating colonic ILF development through the action of IL-25 on IL-23 and its ability to modulate Treg differentiation. Colonic ILF develop in the absence of a number of factors required for 30 the development of their SI counterparts and can be specifically suppressed by factors other than IL-25. However, IL-23 is the only factor identified that specifically promotes colonic ILF without affecting SI-ILF development. Both IL-23 and ILF are associated with inflammatory bowel disease, suggesting that disruption to this pathway may have an important role in the breakdown of microbiota-immune homeostasis.
|Early online date||24 Sep 2014|
|Publication status||Published - May 2015|
FingerprintDive into the research topics of 'Reciprocal Regulation of Lymphoid Tissue Development in the Large Intestine by IL-25 and IL-23: Regulation of colonic ILF by IL-25/IL-23'. Together they form a unique fingerprint.
- 5 Finished
Gill, A., Barron, R., Beard, P., Brunton, P., Goldmann, W., Hume, D., Hunter, N., Lawrence, A., Mabbott, N., Manson, J., McColl, B., Meddle, S. & Wishart, T.
1/04/12 → 31/03/17
Biolayout Express3d: a community resource for the network visulisation and analysis of biological data and pathways
Freeman, T. & Enright, A. J.
1/07/10 → 29/11/13
- Royal (Dick) School of Veterinary Studies - Personal Chair of Immunopathology
- Edinburgh Neuroscience
- Edinburgh Imaging
Person: Academic: Research Active