TY - JOUR
T1 - Recommendations for Minimum Information for Publication of Experimental Pathology Data: MINPEPA Guidelines
A2 - Scudamore, C
A2 - Soilleux, Elizabeth J
A2 - Karp, Natasha A
A2 - Smith, Ken
A2 - Poulsom, Richard
A2 - Herrington, Charles
A2 - Day, Michael
A2 - Brayton, Cory
A2 - Bolon, Brad
A2 - Whitelaw, Christopher
A2 - White, Eric
A2 - Everitt, Jeffrey
A2 - Arends, Mark
PY - 2016/1
Y1 - 2016/1
N2 - Animal models are essential research tools in modern biomedical research, but there are concerns about their lack of reproducibility and the failure of animal data to translate into advances in human medical therapy. A major factor in improving experimental reproducibility is thorough communication of research methodologies. The recently published ARRIVE guidelines outline basic information that should be provided when reporting animal studies. This paper builds on ARRIVE by providing the minimum information needed in reports to allow proper assessment of pathology data gathered from animal tissues. This guidance covers aspects of experimental design, technical procedures, data gathering, analysis and presentation that are potential sources of variation when creating morphological, immunohistochemical (IHC) or in situ hybridisation (ISH) datasets. This reporting framework will maximise the likelihood that pathology data derived from animal experiments can be reproduced by ensuring that sufficient information is available to allow for replication of the methods and facilitate inter-study comparison by identifying potential interpretative confounders.
AB - Animal models are essential research tools in modern biomedical research, but there are concerns about their lack of reproducibility and the failure of animal data to translate into advances in human medical therapy. A major factor in improving experimental reproducibility is thorough communication of research methodologies. The recently published ARRIVE guidelines outline basic information that should be provided when reporting animal studies. This paper builds on ARRIVE by providing the minimum information needed in reports to allow proper assessment of pathology data gathered from animal tissues. This guidance covers aspects of experimental design, technical procedures, data gathering, analysis and presentation that are potential sources of variation when creating morphological, immunohistochemical (IHC) or in situ hybridisation (ISH) datasets. This reporting framework will maximise the likelihood that pathology data derived from animal experiments can be reproduced by ensuring that sufficient information is available to allow for replication of the methods and facilitate inter-study comparison by identifying potential interpretative confounders.
U2 - 10.1002/path.4642
DO - 10.1002/path.4642
M3 - Literature review
SN - 0022-3417
VL - 238
SP - 359
EP - 367
JO - The Journal of Pathology
JF - The Journal of Pathology
IS - 2
ER -