Reconstruction of major fibers using 7T multi-shell Hybrid Diffusion Imaging in mice

Madelaine Daianu, Russell E. Jacobs, Berislav V. Zlokovic, Axel Montagne, Paul M. Thompson

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract / Description of output

Diffusion weighted imaging (DWI) can reveal the orientation of the underlying fiber populations in the brain. High angular resolution diffusion imaging (HARDI) is increasingly used to better resolve the orientation and mixing of fibers. Here, we assessed the added value of multi-shell q-space sampling on the reconstruction of major fibers using mathematical frameworks from q-ball imaging (QBI) and generalized q-sampling imaging (GQI), as compared to diffusion tensor imaging (DTI). We scanned a healthy mouse brain using 7-Tesla 5-shell HARDI (b=1000, 3000, 4000, 8000, 12000 s/mm2), also known as hybrid diffusion imaging (HYDI). We found that QBI may provide greater reconstruction accuracy for major fibers, which improves with the addition of higher b-value shells, unlike GQI or DTI (as expected). Although QBI is a special case of GQI, the major fiber orientation in QBI was more closely related to the orientation in DTI, rather than GQI. HYDI can aid the clinical outcomes of research and especially-more advanced human and animal connectomics projects to map the brainâs neural pathways and networks.

Original languageEnglish
Title of host publication11th International Symposium on Medical Information Processing and Analysis
EditorsJuan D. Garcia-Arteaga, Jorge Brieva, Natasha Lepore, Eduardo Romero
PublisherSPIE
ISBN (Electronic)9781628419160
DOIs
Publication statusPublished - 2015
Event11th International Symposium on Medical Information Processing and Analysis, SIPAIM 2015 - Cuenca, Ecuador
Duration: 17 Nov 201519 Nov 2015

Publication series

NameProceedings of SPIE - The International Society for Optical Engineering
Volume9681
ISSN (Print)0277-786X
ISSN (Electronic)1996-756X

Conference

Conference11th International Symposium on Medical Information Processing and Analysis, SIPAIM 2015
Country/TerritoryEcuador
CityCuenca
Period17/11/1519/11/15

Keywords / Materials (for Non-textual outputs)

  • DWI
  • HARDI
  • HYDI
  • mouse
  • multi-shell
  • QBI

Fingerprint

Dive into the research topics of 'Reconstruction of major fibers using 7T multi-shell Hybrid Diffusion Imaging in mice'. Together they form a unique fingerprint.

Cite this