Recovery of the Response of Sensory Fibers to the Second of a Pair of Peripheral Nerve Stimuli

Emma Brunton, Carolina Silveira, John Riddell, Kianoush Nazarpour

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract / Description of output

Neural interfaces that stimulate the peripheral nerves have the potential to provide sensory feedback from artificial hands. Many neural interfaces are now being developed that allow for multi-channel stimulation of nerves. It is widely accepted that the electric fields generated by two or more contacts on a neural interface can interact. However, this has previously not been examined in the context of sensory feedback prostheses. Here, we aimed to investigate these interactions and the recovery dynamics of the sensory fibers. A multi-channel cuff electrode was implanted on the sciatic nerve of a rat. It comprised four rings (1 mm apart), each containing four circumferentially arranged electrodes. Temporally-patterned pairs of electrical stimuli were delivered through all 120 combinations of electrode pairs. Compound action potentials, elicited by stimulation of the sciatic nerve, were measured with two pairs of hook electrodes placed on the L 4 dorsal root. We find that regardless of the relative position of the two electrodes on the cuff, at an interval of 0 ms, the CAP response is facilitated. At all other intervals, an inter-stimulus interval of even 5 ms was not enough for the response to the second stimulus to fully recover. This observation suggests that overlapping regions of nerve were stimulated. Examining only the intervals where the CAP did not fully recover, we noticed that if the electrodes lay longitudinally, that is, along the nerve, the CAP recovery was significantly impaired, compared to when the electrodes were in any other relative position. The observed space- and time-dependent interactions advocate for further controlled neuroscience studies in parallel to translational work on closed-loop prosthesis control.
Original languageEnglish
Title of host publication2018 40th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC)
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages1214-1217
Number of pages4
ISBN (Electronic)978-1-5386-3646-6
ISBN (Print)978-1-5386-3647-3
DOIs
Publication statusPublished - 29 Oct 2018
Event40th International Conference of the IEEE Engineering in Medicine and Biology Society - Honolulu, United States
Duration: 17 Jul 201821 Jul 2018
https://embc.embs.org/2018/

Publication series

Name
PublisherIEEE
ISSN (Print)1557-170X
ISSN (Electronic)1558-4615

Conference

Conference40th International Conference of the IEEE Engineering in Medicine and Biology Society
Abbreviated titleEMBC 2018
Country/TerritoryUnited States
CityHonolulu
Period17/07/1821/07/18
Internet address

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