Red blood cells from pluripotent stem cells for use in transfusion

Joanne C. Mountford, Emmanuel Oliver, Niove E. Jordanides, Paul de Sousa, Marc L. Turner

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

The use of donated red blood cells in transfusion is a well-established cellular therapy. However, problems including insufficient supply, transfusion-transmitted infections and the need for immunological matching hamper even in the best services. These issues may be eliminated by using pluripotent stem cells to generate universal donor group O, Rhesus D-negative red blood cells. Human embryonic stem cells can be maintained and expanded indefinitely and can, therefore, produce the very large cell numbers required for this application. Red blood cell production is also an attractive goal for pluripotent stem cell-derived therapeutics because it is a well-characterized single cell suspension, lacking nucleated cells and with a low expression of HLA molecules. Much progress has been made; however, a number of challenges remain including scale-up, clinical effectiveness and product safety.

Original languageEnglish
Pages (from-to)411-423
Number of pages13
JournalRegenerative medicine
Issue number3
Publication statusPublished - May 2010


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