Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

Anissa A.  Widjaja; Jinrui  Dong; Eleonora Adami; Sivakumar  Viswanathan; Benjamin K Ng; Leroy S.  Pakkiri; Sonia P.  Chothani; Brijesh K.  Singh; Wei Wen  Lim; Jin  Zhou; Shamini G.  Shekeran; Jessie  Tan; Sze Yun  Lim; Joyce  Goh; Mao Wang; Robert  Holgate; Arron  Hearn; Leanne E.  Felkin; Paul M.  Yen; James W Dear; Chester Lee  Drum; Sebastian Schafer; Stuart A Cook

doi:10.1126/scitranslmed.aba8146

Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

Anissa A. Widjaja, Jinrui Dong, Eleonora Adami, Sivakumar Viswanathan, Benjamin K Ng, Leroy S. Pakkiri, Sonia P. Chothani, Brijesh K. Singh, Wei Wen Lim, Jin Zhou, Shamini G. Shekeran, Jessie Tan, Sze Yun Lim, Joyce Goh, Mao Wang, Robert Holgate, Arron Hearn, Leanne E. Felkin, Paul M. Yen, James W DearChester Lee Drum, Sebastian Schafer, Stuart A Cook

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Science Translational Medicine
Early online date	9 Jun 2021
DOIs	https://doi.org/10.1126/scitranslmed.aba8146
Publication status	E-pub ahead of print - 9 Jun 2021

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https://jcmr-online.biomedcentral.com/articles/10.1186/s12968-021-00756-x

Cite this

Widjaja, A. A., Dong, J., Adami, E., Viswanathan, S., Ng, B. K., Pakkiri, L. S., Chothani, S. P., Singh, B. K., Lim, W. W., Zhou, J., Shekeran, S. G., Tan, J., Lim, S. Y., Goh, J., Wang, M., Holgate, R., Hearn, A., Felkin, L. E., Yen, P. M., ... Cook, S. A. (2021). Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury. Science Translational Medicine. Advance online publication. https://doi.org/10.1126/scitranslmed.aba8146

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title = "Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury",

author = "Widjaja, {Anissa A.} and Jinrui Dong and Eleonora Adami and Sivakumar Viswanathan and Ng, {Benjamin K} and Pakkiri, {Leroy S.} and Chothani, {Sonia P.} and Singh, {Brijesh K.} and Lim, {Wei Wen} and Jin Zhou and Shekeran, {Shamini G.} and Jessie Tan and Lim, {Sze Yun} and Joyce Goh and Mao Wang and Robert Holgate and Arron Hearn and Felkin, {Leanne E.} and Yen, {Paul M.} and Dear, {James W} and Drum, {Chester Lee} and Sebastian Schafer and Cook, {Stuart A}",

year = "2021",

month = jun,

day = "9",

doi = "10.1126/scitranslmed.aba8146",

language = "English",

journal = "Science Translational Medicine",

issn = "1946-6234",

publisher = "American Association for the Advancement of Science",

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Widjaja, AA, Dong, J, Adami, E, Viswanathan, S, Ng, BK, Pakkiri, LS, Chothani, SP, Singh, BK, Lim, WW, Zhou, J, Shekeran, SG, Tan, J, Lim, SY, Goh, J, Wang, M, Holgate, R, Hearn, A, Felkin, LE, Yen, PM, Dear, JW, Drum, CL, Schafer, S & Cook, SA 2021, 'Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury', Science Translational Medicine. https://doi.org/10.1126/scitranslmed.aba8146

TY - JOUR

T1 - Redefining IL11 as a regeneration-limiting hepatotoxin and therapeutic target in acetaminophen-induced liver injury

AU - Widjaja, Anissa A.

AU - Dong, Jinrui

AU - Adami, Eleonora

AU - Viswanathan, Sivakumar

AU - Ng, Benjamin K

AU - Pakkiri, Leroy S.

AU - Chothani, Sonia P.

AU - Singh, Brijesh K.

AU - Lim, Wei Wen

AU - Zhou, Jin

AU - Shekeran, Shamini G.

AU - Tan, Jessie

AU - Lim, Sze Yun

AU - Goh, Joyce

AU - Wang, Mao

AU - Holgate, Robert

AU - Hearn, Arron

AU - Felkin, Leanne E.

AU - Yen, Paul M.

AU - Dear, James W

AU - Drum, Chester Lee

AU - Schafer, Sebastian

AU - Cook, Stuart A

PY - 2021/6/9

Y1 - 2021/6/9

U2 - 10.1126/scitranslmed.aba8146

DO - 10.1126/scitranslmed.aba8146

M3 - Article

SN - 1946-6234

JO - Science Translational Medicine

JF - Science Translational Medicine

ER -