Redefining precision radiotherapy through liquid biopsy

Duncan McLaren; Timothy J. Aitman

doi:10.1038/s41416-023-02398-5

Redefining precision radiotherapy through liquid biopsy

Duncan McLaren^*, Timothy J. Aitman^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Precision radiotherapy refers to the ability to deliver radiation doses with sub-millimetre accuracy. It does not however consider individual variation in tumour or normal tissue response, failing to maximise tumour control and minimise toxicity. Combining precise delivery with personalised dosing, through analysis of cell-free DNA, would redefine precision in radiotherapy.

Original language	English
Pages (from-to)	900-903
Journal	British Journal of Cancer
Volume	129
Issue number	6
Early online date	19 Aug 2023
DOIs	https://doi.org/10.1038/s41416-023-02398-5
Publication status	Published - 5 Oct 2023

Keywords / Materials (for Non-textual outputs)

Cell-Free Nucleic Acids
Humans
Liquid Biopsy
Radiation Oncology

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10.1038/s41416-023-02398-5Licence: Creative Commons: Attribution (CC-BY)

OA_s41416-023-02398-5
Open Access. This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creat iveco mmons. org/ licen ses/ by/4. 0/.
Final published version, 950 KBLicence: Creative Commons: Attribution (CC-BY)

Cite this

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title = "Redefining precision radiotherapy through liquid biopsy",

abstract = "Precision radiotherapy refers to the ability to deliver radiation doses with sub-millimetre accuracy. It does not however consider individual variation in tumour or normal tissue response, failing to maximise tumour control and minimise toxicity. Combining precise delivery with personalised dosing, through analysis of cell-free DNA, would redefine precision in radiotherapy.",

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AU - Aitman, Timothy J.

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AB - Precision radiotherapy refers to the ability to deliver radiation doses with sub-millimetre accuracy. It does not however consider individual variation in tumour or normal tissue response, failing to maximise tumour control and minimise toxicity. Combining precise delivery with personalised dosing, through analysis of cell-free DNA, would redefine precision in radiotherapy.

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Redefining precision radiotherapy through liquid biopsy

Abstract

Keywords / Materials (for Non-textual outputs)

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