Redefining the ACE-inhibitor dose-response relationship: substantial blood pressure lowering after massive doses

G A Christie, Christopher Lucas, D N Bateman, W S Waring

Research output: Contribution to journalArticlepeer-review

Abstract

The blood pressure-lowering dose-response relationship for angiotensin converting enzyme (ACE) inhibitors is assumed to flatten at doses higher than those conventionally used in clinical practice. However, existing clinical trial data do not adequately address the haemodynamic effects of high ACE inhibitor dosages. Therefore, we examined the blood pressure responses in patients presenting to hospital following a deliberate ACE inhibitor overdose.
Original languageEnglish
Pages (from-to)989-93
Number of pages5
JournalEuropean journal of clinical pharmacology
Volume62
Issue number12
DOIs
Publication statusPublished - 2006

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