Redox-based protein modifications: The missing link in plant immune signalling

Steven H. Spoel, Gary J. Loake

Research output: Contribution to journalLiterature reviewpeer-review

Abstract / Description of output

Activation of plant immunity is associated with dramatic changes in the cellular redox status. Both oxidative and reductive bursts have been described that trigger a set of down stream responses resulting in reprogramming of the transcriptome and establishment of disease resistance. Nonetheless, how these redox changes are sensed and signal to downstream regulators remained a missing link in studies of plant immunity. Emerging evidence now indicates that pathogen-induced changes in the cellular redox environment are sensed by reactive cysteine residues of key regulatory proteins. Varying degrees of reversible, oxidative cysteine modifications control the activity, localization, protein-interaction and stability of regulatory proteins. These diverse effects on protein function make post-translational redox-based modifications potent modulators of plant immunity.

Original languageEnglish
Pages (from-to)358-364
Number of pages7
JournalCurrent opinion in plant biology
Issue number4
Publication statusPublished - Aug 2011


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