Reduced adhesion between cells and substrate confers selective advantage in bacterial colonies

Craig Watson, Paul Hush, Joshua Williams, Angela Dawson, Nikola Ojkic, Simon Titmuss, Bartlomiej Waclaw

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Microbial colonies cultured on agar Petri dishes have become a model system to study biological evolution in populations expanding in space. Processes such as clonal segregation and gene surfing have been shown to be affected by interactions between microbial cells and their environment. In this work we investigate the role of mechanical interactions such as cell-surface adhesion. We compare two strains of the bacterium E. coli: a wild-type strain and a "shaved" strain that adheres less to agar. We show that the shaved strain has a selective advantage over the wild type: although both strains grow with the same rate in liquid media, the shaved strain produces colonies that expand faster on agar. This allows the shaved strain outgrow the wild type when both strains compete for space. We hypothesise that, in contrast to a more common scenario in which selective advantage results from increased growth rate, the higher fitness of the shaved strain is caused by reduced adhesion and friction with the agar surface.
Original languageEnglish
JournalEuropean Physical Society Letters (EPL)
Early online date3 Oct 2018
DOIs
Publication statusPublished - 3 Oct 2018

Keywords / Materials (for Non-textual outputs)

  • q-bio.PE
  • physics.bio-ph

Fingerprint

Dive into the research topics of 'Reduced adhesion between cells and substrate confers selective advantage in bacterial colonies'. Together they form a unique fingerprint.

Cite this