Reduced bone mass and muscle strength in male 5α-reductase type 1 inactivated mice

Sara H Windahl, Niklas Andersson, Anna Borjesson, Charlotte Swanson, Johan Svensson, Sofia Movérare-Skrtic, Klara Sjögren, Ruijin Shao, Marie K Lagerquist, Claes Ohlsson

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Androgens are important regulators of bone mass but the relative importance of testosterone (T) versus dihydrotestosterone (DHT) for the activation of the androgen receptor (AR) in bone is unknown. 5α-reductase is responsible for the irreversible conversion of T to the more potent AR activator DHT. There are two well established isoenzymes of 5α-reductase (type 1 and type 2), encoded by separate genes (Srd5a1 and Srd5a2). 5α-reductase type 2 is predominantly expressed in male reproductive tissues whereas 5α-reductase type 1 is highly expressed in liver and moderately expressed in several other tissues including bone. The aim of the present study was to investigate the role of 5α-reductase type 1 for bone mass using Srd5a1⁻/⁻ mice. Four-month-old male Srd5a1⁻/⁻ mice had reduced trabecular bone mineral density (-36%, p
Original languageEnglish
Pages (from-to)e21402
JournalPLoS ONE
Volume6
Issue number6
DOIs
Publication statusPublished - 2011

Keywords / Materials (for Non-textual outputs)

  • 3-Oxo-5-alpha-Steroid 4-Dehydrogenase
  • Androgens
  • Animals
  • Body Weight
  • Bone Density
  • Bone and Bones
  • Enzyme Activation
  • Female
  • Forelimb
  • Gene Expression Profiling
  • Hand Strength
  • Isoenzymes
  • Male
  • Membrane Proteins
  • Mice
  • Mice, Knockout
  • Muscle Strength
  • Orchiectomy
  • Organ Size
  • Ovary
  • RNA, Messenger
  • Receptors, Prolactin
  • Testosterone
  • Viscera

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