Reduced dementia incidence after varicella zoster vaccination in Wales 2013-2020

Christian Schnier; Janet Janbek; Richard Lathe; Jürgen Haas

doi:10.1002/trc2.12293

Reduced dementia incidence after varicella zoster vaccination in Wales 2013-2020

Christian Schnier, Janet Janbek, Richard Lathe, Jürgen Haas

Research output: Contribution to journal › Article › peer-review

Abstract

INTRODUCTION: Chronic infection with herpes viruses is a potential contributing factor to the development of dementia. The introduction of nationwide shingles (varicella zoster) vaccination in Wales might therefore be associated with reduced incident dementia.

METHODS: We analyzed the association of shingles vaccination with incident dementia in Wales between 2013 and 2020 using retrospectively collected national health data.

RESULTS: Vaccinated individuals were at reduced risk of dementia (adjusted hazard ratio: 0.72; 95% confidence interval: 0.69 to 0.75). The association was not modified by a reduction in shingles diagnosis and was stronger for vascular dementia than for Alzheimer's disease. Vaccination was also associated with a reduction in several other diseases and all-cause mortality.

DISCUSSION: Our study shows a clear association of shingles vaccination with reduced dementia, consistent with other observational cohort studies. The association may reflect selection bias with people choosing to be vaccinated having a higher healthy life expectancy.

Original language	English
Article number	e12293
Journal	Alzheimer's and Dementia: Translational Research and Clinical Interventions
Volume	8
Issue number	1
Early online date	13 Apr 2022
DOIs	https://doi.org/10.1002/trc2.12293
Publication status	E-pub ahead of print - 13 Apr 2022

Access to Document

10.1002/trc2.12293

A D Transl Res Clin Interv - 2022 - Schnier - Reduced dementia incidence after varicella zoster vaccination in Wales 2013Final published version, 625 KBLicence: Creative Commons: Attribution (CC-BY)

Cite this

@article{86f37fb132da49c48383eb3975879cf6,

title = "Reduced dementia incidence after varicella zoster vaccination in Wales 2013-2020",

abstract = "INTRODUCTION: Chronic infection with herpes viruses is a potential contributing factor to the development of dementia. The introduction of nationwide shingles (varicella zoster) vaccination in Wales might therefore be associated with reduced incident dementia.METHODS: We analyzed the association of shingles vaccination with incident dementia in Wales between 2013 and 2020 using retrospectively collected national health data.RESULTS: Vaccinated individuals were at reduced risk of dementia (adjusted hazard ratio: 0.72; 95% confidence interval: 0.69 to 0.75). The association was not modified by a reduction in shingles diagnosis and was stronger for vascular dementia than for Alzheimer's disease. Vaccination was also associated with a reduction in several other diseases and all-cause mortality.DISCUSSION: Our study shows a clear association of shingles vaccination with reduced dementia, consistent with other observational cohort studies. The association may reflect selection bias with people choosing to be vaccinated having a higher healthy life expectancy.",

author = "Christian Schnier and Janet Janbek and Richard Lathe and J{\"u}rgen Haas",

note = "{\textcopyright} 2022 The Authors. Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring published by Wiley Periodicals, LLC on behalf of Alzheimer's Association.",

year = "2022",

month = apr,

day = "13",

doi = "10.1002/trc2.12293",

language = "English",

volume = "8",

journal = "Alzheimer's and Dementia: Translational Research and Clinical Interventions",

issn = "2352-8737",

publisher = "Elsevier",

number = "1",

}

TY - JOUR

T1 - Reduced dementia incidence after varicella zoster vaccination in Wales 2013-2020

AU - Schnier, Christian

AU - Janbek, Janet

AU - Lathe, Richard

AU - Haas, Jürgen

PY - 2022/4/13

Y1 - 2022/4/13

N2 - INTRODUCTION: Chronic infection with herpes viruses is a potential contributing factor to the development of dementia. The introduction of nationwide shingles (varicella zoster) vaccination in Wales might therefore be associated with reduced incident dementia.METHODS: We analyzed the association of shingles vaccination with incident dementia in Wales between 2013 and 2020 using retrospectively collected national health data.RESULTS: Vaccinated individuals were at reduced risk of dementia (adjusted hazard ratio: 0.72; 95% confidence interval: 0.69 to 0.75). The association was not modified by a reduction in shingles diagnosis and was stronger for vascular dementia than for Alzheimer's disease. Vaccination was also associated with a reduction in several other diseases and all-cause mortality.DISCUSSION: Our study shows a clear association of shingles vaccination with reduced dementia, consistent with other observational cohort studies. The association may reflect selection bias with people choosing to be vaccinated having a higher healthy life expectancy.

AB - INTRODUCTION: Chronic infection with herpes viruses is a potential contributing factor to the development of dementia. The introduction of nationwide shingles (varicella zoster) vaccination in Wales might therefore be associated with reduced incident dementia.METHODS: We analyzed the association of shingles vaccination with incident dementia in Wales between 2013 and 2020 using retrospectively collected national health data.RESULTS: Vaccinated individuals were at reduced risk of dementia (adjusted hazard ratio: 0.72; 95% confidence interval: 0.69 to 0.75). The association was not modified by a reduction in shingles diagnosis and was stronger for vascular dementia than for Alzheimer's disease. Vaccination was also associated with a reduction in several other diseases and all-cause mortality.DISCUSSION: Our study shows a clear association of shingles vaccination with reduced dementia, consistent with other observational cohort studies. The association may reflect selection bias with people choosing to be vaccinated having a higher healthy life expectancy.

U2 - 10.1002/trc2.12293

DO - 10.1002/trc2.12293

M3 - Article

C2 - 35434253

SN - 2352-8737

VL - 8

JO - Alzheimer's and Dementia: Translational Research and Clinical Interventions

JF - Alzheimer's and Dementia: Translational Research and Clinical Interventions

IS - 1

M1 - e12293

ER -

Reduced dementia incidence after varicella zoster vaccination in Wales 2013-2020

Abstract

Access to Document

Fingerprint

Cite this