Reduced Effectiveness of Selection Caused by a Lack of Recombination

Andrea J. Betancourt, John J. Welch, Brian Charlesworth

Research output: Contribution to journalArticlepeer-review

Abstract

Genetic recombination associated with sexual reproduction is expected to have important consequences for the effectiveness of natural selection. These effects may be evident within genomes, in the form of contrasting patterns of molecular variation and evolution in regions with different levels of recombination. Previous work reveals patterns that are consistent with a benefit of recombination for adaptation at the level of protein sequence: both positive selection for adaptive variants and purifying selection against deleterious ones appear to be compromised in regions of low recombination [1-11]. Here, we re-examine these patterns by using polymorphism and divergence data from the Drosophila dot chromosome, which has a long history of reduced recombination. To avoid confounding selection and demographic effects, we collected these data from a species with an apparently stable demographic history, Drosophila americana. We find that D. americana dot loci show several signatures of ineffective purifying and positive selection, including an increase in the rate of protein evolution, an increase in protein polymorphism, and a reduction in the proportion of amino acid substitutions attributable to positive selection.

Original languageEnglish
Pages (from-to)655-660
Number of pages6
JournalCurrent Biology
Volume19
Issue number8
DOIs
Publication statusPublished - 28 Apr 2009

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